ArticleJournal of gastroenterology and hepatology2019
Comparison of endoscopic ultrasound tissue acquisition methods for genomic analysis of pancreatic cancer.
Article in Journal of gastroenterology and hepatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- Proportion of unresectable pancreatic cancer specimens obtained by endoscopic ultrasound-guided tissue acquisition meeting the OncoGuide™ NCC Oncopanel System analysis suitability criteria: a single-arm, phase II clinical trial.Journal of gastroenterology · 2022Trial
- Efficacy of Endoscopic Ultrasound-guided Fine Needle Biopsy With Simplified Macroscopic On-site Evaluation (With Video).DEN open · 2027Article
- Review
- Role of Endoscopic Ultrasonography in Management of Pancreaticobiliary Cancers: Recent Trends and Advances.Cancers · 2026Review
- Finding More in Less: Precision Medicine for Pancreatic Cancer Using Residual Cytology Samples.Cytopathology : official journal of the British Society for Clinical Cytology · 2026Article
- Diagnostic utility of targeted next-generation sequencing in indeterminate pancreaticobiliary cytology and small biopsy specimens: a prospective cohort study.Virchows Archiv : an international journal of pathology · 2026Article
- Article
- Article
- Correlation Between Endosonography and Cytopathology in the Diagnosis of Pancreatic Masses: A Cross-Sectional Study.Iranian journal of pathology · 2026Article
- Single-Cell Sequencing Unravels Pancreatic Cancer: Novel Technologies Reveal Novel Aspects of Cellular Heterogeneity and Inform Therapeutic Strategies.Biomedicines · 2025Review
- Role of Endoscopic Ultrasound (EUS) in the Era of Precision Medicine for Pancreatic Cancer Through Next-Generation Sequencing Technology.International journal of molecular sciences · 2025Review
- Pancreatic Metastasis From a Vulvar Melanoma Diagnosed by Endoscopic Ultrasound-Guided Fine-Needle Biopsy.ACG case reports journal · 2025Article
- Updated techniques and evidence for endoscopic ultrasound-guided tissue acquisition from solid pancreatic lesions.DEN open · 2025Review
- Diagnostic yield and safety of pancreatic cystic lesions: A comparison between EUSZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Advances in Endoscopic Ultrasonography-Based Diagnosis of Pancreatic Lesions: Narrative Review.Cancers · 2025Review
- Enhancing comprehensive genome profiling of liver tumors using endoscopic ultrasound-guided fine-needle biopsy.Endoscopy international open · 2025Article
- Endoscopic Ultrasound-Guided Pancreatic Tissue Sampling: Lesion Assessment, Needles, and Techniques.Medicina (Kaunas, Lithuania) · 2024Review
- Percutaneous Biopsy and Drainage of the Pancreas.Seminars in interventional radiology · 2024Review
- Review
- Endoscopic Ultrasound and Intraductal Ultrasound in the Diagnosis of Biliary Tract Diseases: A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
4 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
BACKGROUND AND
aimTumor genotyping may allow for improved prognostication and targeted therapy for pancreatic ductal adenocarcinoma (PDAC). We aimed to compare endoscopic ultrasonography (EUS) with fine needle aspiration (FNA) to fine needle biopsy (FNB) for obtaining sufficient tissue for genomic analysis and theranostic potential.
methodsA retrospective cohort study of patients that underwent EUS-FNA or EUS-FNB with either positive or suspicious cytology for PDAC between March 2016 and December 2017. Demographic, procedural, and cytology data were recorded. Genetic alterations were recorded, and Kaplan-Meier survival curves were calculated.
resultsThe study included 167 patients: 145 patients had FNA and 22 patients underwent FNB. Overall, 117 samples (70.1%) were sufficient for targeted next-generation sequencing. FNB resulted in a higher proportion of patients with sufficient samples compared with FNA (90.9% vs 66.9%; P = 0.02). In multivariable modeling, only FNB (odds ratio 4.95, 95% confidence interval 1.11-22.05, P = 0.04) was associated with sufficient sampling for genomic testing. FNB was more likely to obtain sufficient tissue from tumors ≤ 3 cm (100% vs 68.4%, P = 0.017) and tumors located in the head/neck of the pancreas (100% vs 63.1%, P = 0.03) compared with FNA. The most commonly identified alterations were in KRAS (88%), TP53 (68%), and SMAD4 (16%).
conclusionsEndoscopic ultrasonography can reliably obtain sufficient tissue from PDAC for targeted genomic sequencing for prognostication and theranostics. FNB should be considered when tumor genotyping is requested, especially for tumors ≤ 3 cm or tumors located in the head/neck of the pancreas.
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