Trial reportObesity (Silver Spring, Md.)2019
Effectiveness of a Total Meal Replacement Program (OPTIFAST Program) on Weight Loss: Results from the OPTIWIN Study.
Trial report in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Rural-specific OPTIFAST Intervention - A Randomized Study for Partial Remission of Type 2 Diabetes in Patients With Obesity Between the Age of 18 and 65
Effect of Very Low-calorie Diet on the Reduction of Liver Steatosis and Fibrosis in Subjects With Obesity and Non-alcoholic Fatty Liver Disease
The Medically Reproducing Bariatric Surgery (MRB) II Study: SEMAGLUTIDE Followed by OPTIFAST in Veterans With Type 2 Diabetes
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Effects of Incretin-Based Therapies, Diet and Exercise Interventions, and Bariatric Surgery on Fat-Free Mass in Adults With Overweight or Obesity: A Systematic Review and Meta-Analysis.Diabetes, obesity & metabolism · 2026Pooled it
- Preoperative low-energy diets for patients with a body mass index >30 kg/m2 undergoing non-bariatric surgery: pilot feasibility randomized clinical trial and a systematic review and meta-analysis of efficacy data.The British journal of surgery · 2026Pooled it
- Meal replacements on obesity and leptin: a systematic review and meta-analysis.Reviews in endocrine & metabolic disorders · 2025Pooled it
- Food- vs. supplement-based very-low-energy diets and gut microbiome composition in women with high body mass index: A randomized controlled trial.Cell reports. Medicine · 2025Trial
- Efficacy of diabetes-specific partial meal replacement on glycemic and weight control in type 2 diabetes: A randomized controlled trial.Diabetes, obesity & metabolism · 2025Trial
- Effects of weight loss and weight loss maintenance on cardiac autonomic function in obesity: a randomized controlled trial.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2023Trial
- Efficacy and Safety of Intragastric Balloon Therapy Compared to a Multidisciplinary Weight Loss Program (OPTIFAST) in a Real-World Population: A Propensity Score Matching Analysis.Obesity facts · 2023Trial
- A high-protein total diet replacement alters the regulation of food intake and energy homeostasis in healthy, normal-weight adults.European journal of nutrition · 2022Trial
- Intermittent and continuous energy restriction result in similar weight loss, weight loss maintenance, and body composition changes in a 6 month randomized pilot study.Clinical obesity · 2021Trial
- Health-Related Quality of Life in Weight Loss Interventions: Results from the OPTIWIN Trial.International journal of environmental research and public health · 2021Trial
- Adherence and weight loss with a total diet replacement programme for increased cancer risk associated with obesity: a UK cohort study.BMJ open · 2026Article
- Lifestyle Change Interventions: Effectiveness of REWIND, a Virtual, Community-Based Weight Management Program.Obesity science & practice · 2025Article
- Evaluating National Trends in Bleeding Associated with Metabolic Bariatric Surgery over 7 Years.Obesity surgery · 2025Article
- Mapping evidence and identifying risks: A systematic scoping review of meal replacements in type 2 diabetes.World journal of diabetes · 2025Article
- Article
- A multidisciplinary approach to weight management and reproductive care: a retrospective cohort study on weight loss through personalized and patient-centered care.Reproductive biology and endocrinology : RB&E · 2025Article
- Article
- Effects of Very Low-Calorie Diet versus Roux-en-Y Gastric Bypass Surgery on Body Composition in Patients with Obesity.Nutrients · 2024Article
- A low-calorie meal replacement improves body composition and metabolic parameters in shift workers with overweight and obesity: a randomized, controlled, parallel group trial.Nutrition & metabolism · 2024Article
- Successful dietary changes correlate with weight-loss outcomes in a new dietary weight-loss program.Obesity science & practice · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this study was to test the effectiveness of the OPTIFAST program (OP), a total meal replacement dietary intervention, compared with a food-based (FB) dietary plan for weight loss.
methodsParticipants with BMI 30 to 55 kg/m
resultsA total of 273 participants (83% of randomized; 135 OP, 138 FB) made up the mITT population. Mean age was 47.1 ± 11.2 years; 82% were female and 71% non-Hispanic white. Baseline BMI was 38.8 ± 5.9 kg/m
conclusionsCompared with an FB approach, OP was more effective with greater sustained weight loss.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.