Evidence map›Paper›PMID 30421803›Full record

ReviewMedical physics2018

In vivo range verification in particle therapy.

Katia Parodi, Jerimy C Polf

Abstract readReview
In one paragraph

Review in Medical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Article
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  7. Review
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  15. Review
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  19. Review
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Katia ParodiDepartment of Medical Physics, Ludwig-Maximilians-Universität München, Am Coulombwall 1, Garching b. Munich, 85748, Germany.
Jerimy C PolfDeparment of Radiation Oncology, Maryland Proton Treatment Center, University of Maryland School of Medicine, 22 South Greene St., Baltimore, MD, 21201, USA.

Funding

Prompt Gamma Imaging for the in-vivo range verification during proton radiotherapyR01CA187416 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI BEDDAR, SAM, KAYE, WILLIAM ROBERT · 2015 to 2019
$2.7M
Cluster of Excellence Munich Centre for Advanced Photonics (MAP)German Research Foundation (DFG)NCI NIH HHS R01 CA187416NCI NIH HHS R01CA187416NIH HHS
6 · The paper itself

Abstract

Exploitation of the full potential offered by ion beams in clinical practice is still hampered by several sources of treatment uncertainties, particularly related to the limitations of our ability to locate the position of the Bragg peak in the tumor. To this end, several efforts are ongoing to improve the characterization of patient position, anatomy, and tissue stopping power properties prior to treatment as well as to enable in vivo verification of the actual dose delivery, or at least beam range, during or shortly after treatment. This contribution critically reviews methods under development or clinical testing for verification of ion therapy, based on pretreatment range and tissue probing as well as the detection of secondary emissions or physiological changes during and after treatment, trying to disentangle approaches of general applicability from those more specific to certain anatomical locations. Moreover, it discusses future directions, which could benefit from an integration of multiple modalities or address novel exploitation of the measurable signals for biologically adapted therapy.

Indexed as

HumansPositron-Emission TomographyRadiotherapy, Image-GuidedUncertaintyin vivo range verificationion transmission imagingparticle therapy

Identifiers

PMID30421803
PMCPMC6262833

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.