ArticleACS applied materials & interfaces2018
Chitosan-Lysozyme Conjugates for Enzyme-Triggered Hydrogel Degradation in Tissue Engineering Applications.
Article in ACS applied materials & interfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 130 citations in OpenAlex.
- Innovative Hydroxyapatite-Hydrogel Composites for Cartilage Regeneration.Gels (Basel, Switzerland) · 2026Review
- Biomass-Derived Hydrogels for Load-Bearing Connective Tissue Repair: Integrative Reinforcement, Bio-Functional Design, and Emerging Pathways Toward Clinical Translation.Advanced healthcare materials · 2026Review
- Chitosan-Based Hydrogels in Vascular Tissue Engineering Applications.Materials (Basel, Switzerland) · 2026Review
- Antimicrobial sonodynamic therapy: Recent advances and challenges in new therapeutic approaches to antimicrobials.Journal of pharmaceutical analysis · 2026Review
- Assessment of Sealing Ability and Degradation Resistance of a Hydrogel-Based Root Canal Filling Material Using a Bacterial Leakage Model and SEM Analysis.BioMed research international · 2026Article
- Chitosan Sponges as Next-Generation Biomaterials for Dental Tissue Engineering and Periodontal Regeneration.Pharmaceutics · 2025Review
- Development of injectable cuttlebone derived nanohydroxyapatite hydrogel for osteoblast cell encapsulation.Biochemistry and biophysics reports · 2025Article
- A Hydro-Expansive and Degradable Biomaterial Enabling Shape Recovery of Film-Based Devices in Biofluids.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- UV-Triggered Cascading Degradation of Silicone Elastomer via Self-Fluoride Amplification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Catalyst-modulated hydrogel dynamics for decoupling viscoelasticity and directing macrophage fate for diabetic wound healing.Bioactive materials · 2025Article
- Bioinspired smart dentin ECM-chitosan hydrogels for dentin-pulp complex regeneration.Journal of dentistry · 2025Article
- Bioengineered Injectable Hydrogel Based on the Dentin Extracellular Matrix and Chitosan.ACS omega · 2025Article
- Immunocytochemistry response of a hybrid (chitosan-RSC advances · 2025Article
- Chitosan Micro/Nanocapsules in Action: Linking Design, Production, and Therapeutic Application.Molecules (Basel, Switzerland) · 2025Review
- Review
- Rapid Synthesis of Robust Antibacterial and Biodegradable Hydrogels via Frontal Polymerization.Gels (Basel, Switzerland) · 2023Article
- The Diamond Concept Enigma: Recent Trends of Its Implementation in Cross-linked Chitosan-Based Scaffolds for Bone Tissue Engineering.ACS applied bio materials · 2023Review
- Hydrogel Drug Delivery Systems for Bone Regeneration.Pharmaceutics · 2023Review
- Self-healing hybrid hydrogels with sustained bioactive components release for guided bone regeneration.Journal of nanobiotechnology · 2023Article
- Preparation and In Vitro Evaluation of Chitosan-g-Oligolactide Based Films and Macroporous Hydrogels for Tissue Engineering.Polymers · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Tuning hydrogel degradation enables effective and successful tissue regeneration by modulating cellular behaviors and matrix formation. In this work, we develop a novel degradable hydrogel scaffold on the basis of a unique enzyme-substrate complex by photocrosslinking. Chitosan and lysozyme are chemically modified with methacrylate moieties to be tethered in hydrogels, and in the presence of riboflavin initiator, these hydrogels are cured by blue light irradiation. The incorporation of lysozyme to chitosan hydrogels accelerates the degradation rate of the crosslinked hydrogels in a dose-dependent manner, as evidenced by an increase in pore size and interconnectivity through cryogenic scanning electron microscopy over time. Those noncytotoxic materials significantly enhance cellular proliferation and migration, which contribute to osteogenic differentiation of encapsulated mesenchymal stem cells in vitro and bone formation in mouse calvarial defects. These findings suggest a promising strategy to modulate the degradation behavior of hydrogels for use in tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.