ArticleEnvironmental microbiology2019
Gene cluster conservation identifies melanin and perylenequinone biosynthesis pathways in multiple plant pathogenic fungi.
Article in Environmental microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Sulphopreussomerins: Sulfur-Containing Preussomerins Isolated from the Marine-Derived Fungus Pyrenochaetopsis indica.Journal of natural products · 2026Article
- Induced effect of NaWorld journal of microbiology & biotechnology · 2025Article
- Intra-Leaf Variability of Incubation Period Sheds New Light on the Lifestyle ofJournal of fungi (Basel, Switzerland) · 2025Article
- Regulation of melanin production in fungi.Frontiers in fungal biology · 2025Review
- Genomic features of lichen-associated black fungi.IUBMB life · 2025Article
- Six type-I PKS classes and highly conserved melanin and elsinochrome gene clusters found in diverse Elsinoë species.BMC genomics · 2024Article
- Transcriptome Analysis Reveals Candidate Genes for Light Regulation of Elsinochrome Biosynthesis inMicroorganisms · 2024Article
- Cercospora leaf spot disease of sugar beet.Plant signaling & behavior · 2023Review
- A putative terpene cyclase gene (Frontiers in microbiology · 2023Article
- Article
- An Unconventional Melanin Biosynthesis Pathway in Ustilago maydis.Applied and environmental microbiology · 2021Article
- Cercospora beticola: The intoxicating lifestyle of the leaf spot pathogen of sugar beet.Molecular plant pathology · 2020Article
- Identification of an intermediate for 1,8-dihydroxynaphthalene-melanin synthesis in a race-2 isolate ofHeliyon · 2018Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Perylenequinones are a family of structurally related polyketide fungal toxins with nearly universal toxicity. These photosensitizing compounds absorb light energy which enables them to generate reactive oxygen species that damage host cells. This potent mechanism serves as an effective weapon for plant pathogens in disease or niche establishment. The sugar beet pathogen Cercospora beticola secretes the perylenequinone cercosporin during infection. We have shown recently that the cercosporin toxin biosynthesis (CTB) gene cluster is present in several other phytopathogenic fungi, prompting the search for biosynthetic gene clusters (BGCs) of structurally similar perylenequinones in other fungi. Here, we report the identification of the elsinochrome and phleichrome BGCs of Elsinoë fawcettii and Cladosporium phlei, respectively, based on gene cluster conservation with the CTB and hypocrellin BGCs. Furthermore, we show that previously reported BGCs for elsinochrome and phleichrome are involved in melanin production. Phylogenetic analysis of the corresponding melanin polyketide synthases (PKSs) and alignment of melanin BGCs revealed high conservation between the established and newly identified C. beticola, E. fawcettii and C. phlei melanin BGCs. Mutagenesis of the identified perylenequinone and melanin PKSs in C. beticola and E. fawcettii coupled with mass spectrometric metabolite analyses confirmed their roles in toxin and melanin production.
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