Evidence map›Paper›PMID 30421541›Full record

ReviewJournal of sleep research2019

Mechanisms of reduced sleepiness symptoms in heart failure and obstructive sleep apnea.

Victoria M Pak, Lisa Strouss, Henry K Yaggi, Nancy S Redeker, Vahid Mohsenin, Barbara Riegel

Abstract readReview
In one paragraph

Review in Journal of sleep research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
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  4. Impact of transcatheter edge-to-edge mitral valve repair on central sleep apnoea.Clinical research in cardiology : official journal of the German Cardiac Society · 2023
    Article
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  6. Review
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Victoria M PakCenter for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-4081-8347
Lisa StroussJefferson Medical Center, Philadelphia, Pennsylvania, USA.
Henry K YaggiDepartment of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Nancy S RedekerYale School of Nursing, West Haven, Connecticut, USA.ORCID 0000-0001-7817-2708
Vahid MohseninDepartment of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-9384-8374
Barbara RiegelDepartment of Biobehavioral Research Collaborative, School of Nursing, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-0970-136X

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Mechanisms of Sleepiness Symptoms in Sleep Apnea and Cardiovascular DiseaseR00NR014675 · NINR · YALE UNIVERSITY · PI PAK, VICTORIA M · 2015 to 2017
$699k
Mentoring in Sleep Research and Sleep Interventions in Heart Disease, and StrokeK24HL132093 · NHLBI · YALE UNIVERSITY · PI YAGGI, HENRY KLAR · 2016 to 2020
$336k
Mechanisms of Sleepiness Symptoms in Sleep Apnea and Cardiovascular DiseaseK99NR014675 · NINR · UNIVERSITY OF PENNSYLVANIA · PI PAK, VICTORIA M · 2013 to 2014
$180k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K24 HL132093NINR NIH HHS K99 NR014675NINR NIH HHS R00 NR014675
6 · The paper itself

Abstract

Patients with both heart failure and obstructive sleep apnea often have poor, repeatedly disrupted sleep, and yet they frequently do not complain of excessive daytime sleepiness. Understanding this lack of perceived sleepiness is crucial for the case identification and treatment of obstructive sleep apnea in the heart failure population at high risk of this disease, especially given the association between untreated obstructive sleep apnea and mortality among patients with heart failure. In this review, we present epidemiologic evidence concerning the lack of sleepiness symptoms in heart failure and obstructive sleep apnea, explore possible mechanistic explanations for this relationship, assess the benefits of treatment in this population, discuss implications for clinical practice and explore directions for future research.

Indexed as

FemaleHeart FailureHumansMaleMiddle AgedSleep Apnea, ObstructiveWakefulnessadultscardiovascular diseasedaytime sleepiness

Identifiers

PMID30421541
PMCPMC6538477

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.