ArticleBipolar disorders2019
Lithium monotherapy associated longitudinal effects on resting state brain networks in clinical treatment of bipolar disorder.
Article in Bipolar disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Lithium effects in the frontolimbic circuitry: a systematic review of neuroimaging findings in bipolar disorder.Translational psychiatry · 2026Pooled it
- Different Changes in Brain Functional Networks Following 12-Week Psychostimulant Treatment in Attention-Deficit/Hyperactivity Disorder Youth With and Without Familial Risk for Bipolar I Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Trial
- Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder.Biological psychiatry · 2026Article
- Revisiting the cognitive potential of lithium in alzheimer's disease: the role of cholinergic system and brain connectivity.Translational psychiatry · 2026Review
- The application of amplitude of low-frequency fluctuations metrics in the diagnosis and prediction of treatment response as well as their associated genes and biological processes in patients with bipolar disorder.Translational psychiatry · 2025Article
- Fronto-Parietal and Language Network Connectivity and Its Association With Gene Expression Profiles in Bipolar Disorder Before and After Treatment.CNS neuroscience & therapeutics · 2025Article
- Aberrant resting-state functional network centrality and cognitive impairment in unmedicated, euthymic bipolar patients.BMC psychiatry · 2024Article
- The effect of chronic lithium treatment on hippocampal progenitor cells: Transcriptomic analysis and systems pharmacology.Brain and behavior · 2023Article
- Functional Connectivity of the Cerebellar Vermis in Bipolar Disorder and Associations with Mood.bioRxiv : the preprint server for biology · 2023Article
- Functional connectivity of the cerebellar vermis in bipolar disorder and associations with mood.Frontiers in psychiatry · 2023Article
- Resting-state functional connectivity graph-properties correlate with bipolar disorder-risk in young medication-free depressed subjects: Bipolar-risk Resting State Functional Connectivity in Major Depression.Journal of affective disorders · 2022Article
- The Impact of Lithium on Brain Function in Bipolar Disorder: An Updated Review of Functional Magnetic Resonance Imaging Studies.CNS drugs · 2021Review
- Lithium treatment and human hippocampal neurogenesis.Translational psychiatry · 2021Article
- Aberrant brain network topology in the frontoparietal-limbic circuit in bipolar disorder: a graph-theory study.European archives of psychiatry and clinical neuroscience · 2021Article
- Functional Connectivity between Task-Positive Networks and the Left Precuneus as a Biomarker of Response to Lamotrigine in Bipolar Depression: A Pilot Study.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Schizophrenia and bipolar disorder are associated with opposite brain reward anticipation-associated response.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- A 7 Tesla Amygdalar-Hippocampal Shape Analysis of Lithium Response in Bipolar Disorder.Frontiers in psychiatry · 2021Article
- Resting State Functional Connectivity Biomarkers of Treatment Response in Mood Disorders: A Review.Frontiers in psychiatry · 2021Review
- Neuroanatomic and Functional Neuroimaging Findings.Current topics in behavioral neurosciences · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesLithium is one of the most effective and specific treatments for bipolar disorder (BP), but the neural mechanisms by which lithium impacts symptoms remain unclear. Past research has been limited by a reliance on cross-sectional designs, which does not allow for identification of within-person changes due to lithium and has not examined communication between brain regions (ie, networks). In the present study, we prospectively investigated the lithium monotherapy associated effects in vivo on the brain connectome in medication-free BP patients. In particular, we examined the within-person impact of lithium treatment on connectome indices previously linked to mania and depression in bipolar disorder.
methodsThirty-nine medication-free subjects - 26 BP (13 (hypo)manic and 13 depressed) and 13 closely matched healthy controls (HC) - were included. fMRI data were obtained at 3 timepoints: baseline, after 2 weeks, and after 8 weeks (total of 117 scans: 78 BP and 39 HC scans). BP subjects were clinically treated with lithium for 8 weeks while HC were scanned at the same time points but not treated. Graph theory metrics and repeated measures GLM were used to analyze lithium treatment associated effects.
resultsConsistent with hypotheses, lithium treatment was associated with a normalizing effect on mania-related connectome indices. Furthermore, shifts in both mania- and depression-related connectome indices were proportional to symptom change. Finally, lithium treatment-associated impact on amygdala function differed depending on baseline mood.
conclusionsPresent findings provide deeper insight into the therapeutic neural mechanisms associated with lithium treatment.
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