ArticleAnnals of neurology2018
Thalamic strokes that severely impair arousal extend into the brainstem.
Article in Annals of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness.Frontiers in neurology · 2025Pooled it
- Attentional Deficit as the Primary Manifestation of an Isolated Midbrain Infarction.Internal medicine (Tokyo, Japan) · 2026Article
- Brain network dynamics in the wake-sleep transition reorganize according to task engagement.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Decreased level of consciousness in acute ischemic stroke: risk factors, territories, stroke mechanisms and outcome. A single-centre cohort study.Journal of neurology · 2025Article
- Advances in understanding and treating disorders of consciousness caused by brainstem injury.Chinese neurosurgical journal · 2025Review
- A human brain network linked to restoration of consciousness after deep brain stimulation.Nature communications · 2025Article
- Can Pure Thalamic Strokes Lead to Severe Impairment of Arousal?European journal of neurology · 2025Article
- Automated Measurement of Cerebral Hemorrhagic Contusions and Outcomes After Traumatic Brain Injury in the TRACK-TBI Study.JAMA network open · 2024Article
- Review
- Prevalence, clinical features, and radiological pattern of artery of Percheron infarction: a challenging diagnosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Brain Circuitry of Consciousness: A Review of Current Models and a Novel Synergistic Model With Clinical Application.Neurosurgery practice · 2023Article
- Locked-in syndrome revisited.Therapeutic advances in neurological disorders · 2023Review
- Applications of Advanced MRI to Disorders of Consciousness.Seminars in neurology · 2022Review
- Post-stroke outcomes predicted from multivariate lesion-behaviour and lesion network mapping.Brain : a journal of neurology · 2022Article
- Lesions in different prefrontal sectors are associated with different types of acquired personality disturbances.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Observational
- Thalamo-Prefrontal Connectivity Correlates With Early Command-Following After Severe Traumatic Brain Injury.Frontiers in neurology · 2022Article
- A Century Searching for the Neurons Necessary for Wakefulness.Frontiers in neuroscience · 2022Review
- Structural and functional connectivity of the ascending arousal network for prediction of outcome in patients with acute disorders of consciousness.Scientific reports · 2021Article
- Electrocorticography reveals thalamic control of cortical dynamics following traumatic brain injury.Communications biology · 2021Article
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6 authors at 2 institutions in 1 country.
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Abstract
In this study, we evaluate the role of the thalamus in the neural circuitry of arousal. Level of consciousness within the first 12 hours of a thalamic stroke is assessed with lesion symptom mapping. Impaired arousal correlates with lesions in the paramedian posterior thalamus near the centromedian and parafascicular nuclei, posterior hypothalamus, and midbrain tegmentum. All patients with severely impaired arousal (coma, stupor) had lesion extension into the midbrain and/or pontine tegmentum, whereas purely thalamic lesions did not severely impair arousal. These results are consistent with growing evidence that pathways most critical for human arousal lie outside the thalamus. Ann Neurol 2018;84:926-930.
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