Trial reportIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2018
Study of glutathione S-transferase levels in patients receiving intravenous paracetamol perioperatively: A randomized controlled trial.
Trial report in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Biomarker and hematological fieldwork with amphibians: is it necessary to sample all night?Environmental science and pollution research international · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsMany studies have analyzed the effect of paracetamol on liver functions. The aim of this study was to measure glutathione S-transferase (GST) concentrations in patients receiving intravenous (IV) paracetamol infusions as part of their perioperative pain relief regimen to assess its effect on hepatocellular integrity.
methodsPatients between the ages of 18 and 60 years of both sexes, of American Society of Anesthesiologists (ASA) grades 1 and 2, undergoing laparoscopic gastrointestinal (GI) surgeries were included in the study. Patients in the saline group received three doses of normal saline as placebo 8 h apart, with the first dose administered following the induction of anesthesia. Patients in the paracetamol group received IV paracetamol at identical time points. Blood samples were collected preoperatively, after 1, 6, and at 24 h after induction. GST levels were measured at baseline and after 1, 6, and 24 h in both the groups.
resultsThere was no statistical difference in the demographic variables between the groups. The duration and type of surgery were identical between both the groups. GST values were found to be significantly elevated both within groups, as compared to baseline, and also in the group receiving IV paracetamol as compared to the saline group. Significant elevations of liver enzymes and decrease in serum albumin levels were also noted both within and between the groups at 24 h postoperatively, as compared to the baseline values.
conclusionIntravenous paracetamol infusion during laparoscopic GI surgeries can lead to demonstrable, although subclinical impairment of hepatic function as evident by the rise in levels of GST and hepatic enzymes. Most of such subclinical injury did not progress to clinical hepatic impairment in otherwise healthy patients, as demonstrated by the fact that none of our patients manifested drug-induced hepatitis clinically. ᅟ ᅟ.
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