Evidence map›Paper›PMID 30421379›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2020

The prognostic value of quantitating and localizing F-18 FDG uptake in cardiac sarcoidosis.

R J Flores, K R Flaherty, Z Jin, S Bokhari

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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Diagnostic performance of F-18 FDG PET for detection of cardiac sarcoidosis; A systematic review and meta-analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Pooled it
  2. Guideline
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Patient selection, ventricular tachycardia substrate delineation, and data transfer for stereotactic arrhythmia radioablation: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology and the Heart Rhythm Society.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  8. [Arrhythmias in sarcoidosis].Herzschrittmachertherapie & Elektrophysiologie · 2024
    Review
  9. Review
  10. Cardiac sarcoidosis: diagnosis and management.Frontiers in cardiovascular medicine · 2024
    Review
  11. Prednisone vs methotrexate in treatment naïve cardiac sarcoidosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  12. Review
  13. The role of PET in the management of sarcoidosis.Current opinion in pulmonary medicine · 2022
    Review
  14. Is quantitative fluorine-18 fluorodeoxyglucose PET image analysis the key to Identify cardiac sarcoidosis?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  15. Controversies in the Treatment of Cardiac Sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2022
    Article
  16. Review
  17. Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2020: positron emission tomography, computed tomography, and magnetic resonance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Review
  18. Review
  19. Prognostic insights of molecular imaging in cardiac sarcoidosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  20. State of the art ofClinical and translational imaging · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

R J FloresInternal Medicine, Columbia University Medical Center, New York, NY, USA. raul.jesus.flores@gmail.com.
K R FlahertyInternal Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY, USA.
Z JinDepartment of Biostatistics, Columbia University, New York, NY, USA.
S BokhariInternal Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is no identified level of FDG uptake in cardiac sarcoidosis (CS) associated with increased risk of arrhythmias, conduction disease, heart failure, or death. We aim to utilize standardized uptake value (SUV) quantitation and localization to identify patients at increased risk of cardiac events. METHODS AND

resultsF18-FDG PET/CT with MPI was used in CS diagnosis (N = 67). Mean and max SUV were measured and grouped as basal, mid, and apical disease. Post-scan ventricular tachycardia, AICD placement, complete heart block, pacemaker placement, atrial fibrillation, heart failure, and cardiac-related hospital admissions were recorded (mean follow up 2.98 ± 2 years). Poisson regression analysis revealed that max SUV, mean SUV, as well as mean basal SUV, and LVEF were significantly associated with total cardiac events. Max SUV odds ratio (OR) = 1.068 (95% CI 1.024-1.114, P = 0.002), mean SUV OR = 1.059 (95% CI 1.008-1.113, P = 0.023), mean SUV OR = 1.061 (95% CI 1.012-1.112, P = 0.014), scan LVEF OR = 0.731 (95% CI 0.664-0.805, P < 0.001).

conclusionsSUV at time of CS diagnosis has significant associations with future cardiac events. Patients with higher SUV, particularly in basal segments, are at increased risk of events. Further studies are needed to identify treatment methods utilizing risk stratification of CS.

Indexed as

Fluorodeoxyglucose F18PrognosisAgedCardiomyopathiesFemaleHumansInflammationMaleMiddle AgedOdds RatioPositron-Emission TomographyPositron Emission Tomography Computed TomographyRadiopharmaceuticalsRegression AnalysisReproducibility of ResultsRiskFluorodeoxyglucose F18Radiopharmaceuticalsdiagnostic and prognostic applicationimage analysisinflammationPETSarcoid heart diseasesstatistical analysis

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.