Evidence map›Paper›PMID 30421249›Full record

ArticleMagma (New York, N.Y.)2019

Longitudinal 19F magnetic resonance imaging of brain oxygenation in a mouse model of vascular cognitive impairment using a cryogenic radiofrequency coil.

Ahmed A Khalil, Susanne Mueller, Marco Foddis, Larissa Mosch, Janet Lips, Ingo Przesdzing, Sebastian Temme, Ulrich Flögel, Ulrich Dirnagl, Philipp Boehm-Sturm

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Magma (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. NovelMedical physics · 2025
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ahmed A KhalilDepartment of Experimental Neurology and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. ahmed-abdelrahim.khalil@charite.de.ORCID http://orcid.org/0000-0003-1752-4305
Susanne MuellerDepartment of Experimental Neurology and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0002-5053-2211
Marco FoddisDepartment of Experimental Neurology and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Larissa MoschDepartment of Experimental Neurology and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Janet LipsDepartment of Experimental Neurology and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0003-3011-4386
Ingo PrzesdzingDepartment of Experimental Neurology and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0002-4458-8657
Sebastian TemmeExperimental Cardiovascular Imaging, Molecular Cardiology, Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany.
Ulrich FlögelExperimental Cardiovascular Imaging, Molecular Cardiology, Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0001-7181-4392
Ulrich DirnaglDepartment of Experimental Neurology and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0003-0755-6119
Philipp Boehm-SturmDepartment of Experimental Neurology and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0001-8777-4823
Humboldt-Universität zu Berlin · DEHeinrich Heine University Düsseldorf · DE

Funding

Bundesministerium für Bildung und Forschung 01EO0801Bundesministerium für Bildung und Forschung Center for Stroke Research BerlinDeutsche Forschungsgemeinschaft Exc 257Deutsche Forschungsgemeinschaft NeuroCUREDeutsche Forschungsgemeinschaft SFB 1116Deutsche Forschungsgemeinschaft TE 1209/1-1Deutsche Forschungsgemeinschaft (DE) FL 303/6-1Stiftung Charite BIH_PRO_317
6 · The paper itself

Abstract

introductionWe explored the use of a perfluoro-15-crown-5 ether nanoemulsion (PFC) for measuring tissue oxygenation using a mouse model of vascular cognitive impairment.

methodsSeventeen C57BL/6 mice underwent stereotactic injection of PFC coupled to a fluorophore into the striatum and corpus callosum. Combined 1H/19F magnetic resonance imaging (MRI) to localize the PFC and R

resultsR DISCUSSION: Despite remaining technical challenges, intracerebrally injected PFC is suitable for monitoring brain oxygenation in vivo.

Indexed as

AnimalsBrainCalibrationCognition DisordersCognitive DysfunctionCorpus CallosumCorpus StriatumCrown EthersDisease Models, AnimalEmulsionsFluorineFluorine-19 Magnetic Resonance ImagingFluorocarbonsImage Processing, Computer-AssistedLungMaleCrown EthersEmulsionsFluorineFluorocarbonsOxygenperfluoro-15-crown-5-ether19F-MRIOxygenationPerfluoro-15-crown-5-etherVascular cognitive impairment

Identifiers

PMID30421249
OpenAlexW2901412918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.