Evidence map›Paper›PMID 30421177›Full record

ArticleAnnals of biomedical engineering2019

Linking Physiological Biomarkers of Ventilator-Induced Lung Injury to a Rich-Get-Richer Mechanism of Injury Progression.

Vitor Mori, Bradford J Smith, Bela Suki, Jason H T Bates

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. The POOR Get POORer: A Hypothesis for the Pathogenesis of Ventilator-induced Lung Injury.American journal of respiratory and critical care medicine · 2020
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Vitor MoriDepartment of Medicine, Vermont Lung Center, University of Vermont College of Medicine, 149 Beaumont Ave, HSRF 228, Burlington, VT, 05405, USA.
Bradford J SmithDepartment of Bioengineering, University of Colorado Denver, Aurora, CO, 80045, USA.
Bela SukiDepartment of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
Jason H T BatesDepartment of Medicine, Vermont Lung Center, University of Vermont College of Medicine, 149 Beaumont Ave, HSRF 228, Burlington, VT, 05405, USA. jason.h.bates@uvm.edu.ORCID http://orcid.org/0000-0002-6062-6377
University of Vermont · USBoston University · USUniversity of Colorado Denver · US

Funding

Preserving Epithelial Barrier Integrity in Ventilator-Induced Lung InjuryR01HL142702 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Jason HT Bates, DONALD P. GAVER · 2018 to 2026
$4.6M
A multi-scale computational model of the extracellular matrix of the lungU01HL139466 · NHLBI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI SUKI, BELA · 2018 to 2022
$3.9M
Personalized Mechanical Ventilation for the Injured LungR01HL124052 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BATES, JASON HT · 2014 to 2017
$2.4M
The Importance of Inhomogeneity in the Pathogenesis of Lung InjuryR00HL128944 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SMITH, BRADFORD J · 2017 to 2019
$747k
The Importance of Inhomogeneity in the Pathogenesis of Lung InjuryK99HL128944 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SMITH, BRADFORD J · 2015 to 2016
$224k
CAPES 88881.135413/2016-01National Heart, Lung, and Blood Institute HL124052National Heart, Lung, and Blood Institute HL128944National Heart, Lung, and Blood Institute U01 HL-139466NHLBI NIH HHS R00 HL128944NHLBI NIH HHS R01 HL124052NHLBI NIH HHS R01 HL142702NHLBI NIH HHS U01 HL139466
6 · The paper itself

Abstract

Mechanical ventilation is a crucial tool in the management of acute respiratory distress syndrome, yet it may itself also further damage the lung in a phenomenon known as ventilator-induced lung injury (VILI). We have previously shown in mice that volutrauma and atelectrauma act synergistically to cause VILI. We have also postulated that this synergy arises because of a rich-get-richer mechanism in which repetitive lung recruitment generates initial small holes in the blood-gas barrier which are then expanded by over-distension in a manner that favors large holes over small ones. In order to understand the causal link between this process and the derangements in lung mechanics associated with VILI, we developed a mathematical model that incorporates both atelectrauma and volutrauma to predict how the propensity of the lung to derecruit depends on the accumulation of plasma-derived fluid and proteins in the airspaces. We found that the model accurately predicts derecruitment in mice with experimentally induced VILI.

Indexed as

Models, BiologicalRespiratory Distress SyndromeVentilator-Induced Lung InjuryHumansRespiration, ArtificialAcute respiratory distress syndromeLung mechanicsMechanical ventilationMouse model

Identifiers

PMID30421177
PMCPMC6344242
OpenAlexW2901503094

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.