ArticleMolecular neurobiology2019
Development of Cortical Pyramidal Cell and Interneuronal Dendrites: a Role for Kainate Receptor Subunits and NETO1.
Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 27 citations in OpenAlex.
- Neocortical pyramidal cells with axon-carrying basal dendrites: a prominent feature regulated by activity.Brain structure & function · 2026Article
- Perinatal mAChR-mediated activation of cortical subplate neurons elicits network activity driving basket cell differentiation.Frontiers in cellular neuroscience · 2026Article
- Activation of GluN2D-containing NMDA receptors promotes development of axons and axon-carrying dendrites of cortical interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Chemogenetic activation of Gq signaling modulates dendritic development of cortical neurons in a time- and layer-specific manner.Frontiers in cellular neuroscience · 2025Article
- GluK1 kainate receptors are necessary for functional maturation of parvalbumin interneurons regulating amygdala circuit function.Molecular psychiatry · 2024Article
- Axons of cortical basket cells originating from dendrites develop higher local complexity than axons emerging from basket cell somata.Development (Cambridge, England) · 2023Article
- Extracellular molecular signals shaping dendrite architecture during brain development.Frontiers in cell and developmental biology · 2023Review
- Optogenetic stimulation shapes dendritic trees of infragranular cortical pyramidal cells.Frontiers in cellular neuroscience · 2023Article
- Chemogenetic Silencing of Differentiating Cortical Neurons Impairs Dendritic and Axonal Growth.Frontiers in cellular neuroscience · 2022Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Long-Lived Organotypic Slice Culture Model of the Rat Basolateral Amygdala.Current protocols · 2021Article
- Kainate receptors regulate the functional properties of young adult-born dentate granule cells.Cell reports · 2021Article
- Biolistic transfection and expression analysis of acute cortical slices.Journal of neuroscience methods · 2020Article
- The Kainate Receptor Subunit GluK2 Interacts With KCC2 to Promote Maturation of Dendritic Spines.Frontiers in cellular neuroscience · 2020Article
- Genetically Encoded Calcium Indicators Can Impair Dendrite Growth of Cortical Neurons.Frontiers in cellular neuroscience · 2020Article
- GluN2B but Not GluN2A for Basal Dendritic Growth of Cortical Pyramidal Neurons.Frontiers in neuroanatomy · 2020Article
- Damaging coding variants within kainate receptor channel genes are enriched in individuals with schizophrenia, autism and intellectual disabilities.Scientific reports · 2019Article
- Neto proteins regulate gating of the kainate-type glutamate receptor GluK2 through two binding sites.The Journal of biological chemistry · 2019Article
- NETO1 Regulates Postsynaptic Kainate Receptors in CA3 Interneurons During Circuit Maturation.Molecular neurobiology · 2019Article
- The primate-specific peptide Y-P30 regulates morphological maturation of neocortical dendritic spines.PloS one · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
During neuronal development, AMPA receptors (AMPARs) and NMDA receptors (NMDARs) are important for neuronal differentiation. Kainate receptors (KARs) are closely related to AMPARs and involved in the regulation of cortical network activity. However, their role for neurite growth and differentiation of cortical neurons is unclear. Here, we used KAR agonists and overexpression of selected KAR subunits and their auxiliary neuropilin and tolloid-like proteins, NETOs, to investigate their influence on dendritic growth and network activity in organotypic cultures of rat visual cortex. Kainate at 500 nM enhanced network activity and promoted development of dendrites in layer II/III pyramidal cells, but not interneurons. GluK2 overexpression promoted dendritic growth in pyramidal cells and interneurons. GluK2 transfectants were highly active and acted as drivers for network activity. GluK1 and NETO1 specifically promoted dendritic growth of interneurons. Our study provides new insights for the roles of KARs and NETOs in the morphological and physiological development of the visual cortex.
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