ArticleArchives of osteoporosis2018
Correspondence between bone mineral density and intervertebral disc degeneration across age and sex.
Article in Archives of osteoporosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Does vertebral osteoporosis delay or accelerate lumbar disc degeneration? A systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Pooled it
- A higher threshold of lumbar spine QCT trabecular BMD of < 95 or < 100 mg/mL for fragility fracture risk screening among Caucasian men than that of < 80 mg/mL for Caucasian women.Skeletal radiology · 2026Article
- Article
- Spatial gradient in vertebral-disc coupling: independent associations of bone marrow fat fraction and perfusion with disc biochemistry.BMC musculoskeletal disorders · 2026Article
- Evolutionary Specializations of the Human Vertebral Body and Intervertebral Disc in Relation to Bipedalism.Life (Basel, Switzerland) · 2026Article
- Heterogeneity in Lumbar Segmental Bone Mineral Density and Age-Related Evolution of Whole-Body Bone Mineral Density: Comprehensive Implications for Osteoporosis Risk Assessment.Orthopaedic surgery · 2026Article
- Characterizing aging-related genetic and physiological determinants of spinal curvature.Communications medicine · 2025Article
- Osteoporosis in adjacent cervical segments exacerbates disc herniation.Scientific reports · 2025Article
- The Relationship Between the Heterogeneity of Lumbar Vertebral Trabecular Bone Mineral Density Distribution and Osteoporotic Vertebral Fractures.Calcified tissue international · 2025Article
- Association of vertebral fractures with worsening degenerative changes of the spine: a longitudinal study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- The correlation between self-Hounsfield units and adjacent vertebral fracture after percutaneous vertebral augmentation: a retrospective cohort study.Quantitative imaging in medicine and surgery · 2024Article
- Causal relationship between intervertebral disc degeneration and osteoporosis: a bidirectional two-sample Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Changes in Vertebral Bone Density and Paraspinal Muscle Morphology Following Spaceflight and 1 Year Readaptation on Earth.JBMR plus · 2023Article
- The association of lumbar disc degeneration with lumbar vertebral trabecular volumetric bone mineral density in an urban population of young and middle-aged community-dwelling Chinese adults: a cross-sectional study.Journal of bone and mineral metabolism · 2023Article
- Biomechanical evaluation of position and bicortical fixation of anterior lateral vertebral screws in a porcine model.Scientific reports · 2023Article
- CT based bone mineral density as a predictor of proximal junctional fractures.North American Spine Society journal · 2022Article
- Changes in T2 Relaxation Time Mapping of Intervertebral Discs Adjacent to Vertebrae after Kyphoplasty Correlate with the Physical Clinical Outcome of Patients.Diagnostics (Basel, Switzerland) · 2022Article
- Correlation Analysis between Tamoxifen and Lumbar Intervertebral Disc Degeneration: A Retrospective Case-Control Study.Pain research & management · 2022Article
- Distinctive roles of tumor necrosis factor receptor type 1 and type 2 in a mouse disc degeneration model.Journal of orthopaedic translation · 2021Article
- 3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease.Bone research · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
The distribution of bone tissue within the vertebra can modulate vertebral strength independently of average density and may change with age and disc degeneration. Our results show that the age-associated decrease in bone density is spatially non-uniform and associated with disc health, suggesting a mechanistic interplay between disc and vertebra. PURPOSE: While the decline of bone mineral density (BMD) in the aging spine is well established, the extent to which age influences BMD distribution within the vertebra is less clear. Measures of regional BMD (rBMD) may improve predictions of vertebral strength and suggest how vertebrae might adapt with intervertebral disc degeneration. Thus, we aimed to assess how rBMD values were associated with age, sex, and disc height loss (DHL).
methodsWe measured rBMD in the L3 vertebra of 377 participants from the Framingham Heart Study (41-83 years, 181 M/196 F). Integral (Int.BMD) and trabecular BMD (Tb.BMD) were measured from QCT images. rBMD ratios (anterior/posterior, superior/mid-transverse, inferior/mid-transverse, and central/outer) were calculated from the centrum. A radiologist assigned a DHL severity score to adjacent intervertebral discs (L2-L3 and L3-L4).
resultsInt.BMD and Tb.BMD were both associated with age, though the decrease across age was greater in women (Int.BMD, - 2.6 mg/cm
conclusionsOur results indicate that the distribution of bone within the L3 vertebra is different across age, but not between sexes, and is associated with disc degeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.