Evidence map›Paper›PMID 30421137›Full record

ArticleEndocrine2019

Quality of life assessment in patients with HNF1A-MODY and GCK-MODY.

Magdalena Szopa, Bartlomiej Matejko, Damian Ucieklak, Agata Uchman, Jerzy Hohendorff, Sandra Mrozińska, Wojciech Głodzik, Barbara Zapała, Teresa Płatek, Iwona Solecka and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Endocrine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Identification of pathogenicMolecular genetics and metabolism reports · 2023
    Article
  2. NGS Analysis Revealed Digenic HeterozygousDiagnostics (Basel, Switzerland) · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Magdalena SzopaDepartment of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland.ORCID 0000-0003-4184-419X
Bartlomiej MatejkoDepartment of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland.
Damian UcieklakDepartment of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland.
Agata UchmanDepartment of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland.
Jerzy HohendorffDepartment of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland.
Sandra MrozińskaDepartment of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland.
Wojciech GłodzikSanatio Medical Center, Krakow, Poland.
Barbara ZapałaDepartment of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland.
Teresa PłatekDepartment of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland.
Iwona SoleckaUniversity Hospital, Krakow, Poland.
Cyrus M SaniDepartment of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland.
Maciej T MałeckiDepartment of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland. malecki_malecki@yahoo.com.
Jagiellonian University · PLKrakow Cardiovascular Research Institute · PL

Funding

JUMC Jagiellonian University Medical College Grant (K/ZDS/006219)
6 · The paper itself

Abstract

aimThe impact of maturity onset diabetes of the young (MODY) on quality of life (QoL) has never been examined. We assessed disease impact on QoL among patients with HNF1A-MODY and GCK mutation carrier status.

methodsThe study included 80 patients with HNF1A-MODY and 89 GCK gene mutation carriers. We also examined 128 type 1 diabetes (T1DM) patients for comparison. Diabetes-specific QoL was assessed using the Audit of Diabetes Dependent Quality of Life questionnaire.

resultsHNF1A-MODY and GCK-MODY groups had similar mean age (41.7 vs. 38.0 years, respectively) and BMI (24.1 vs. 24.3 kg/m

conclusionMODY has a smaller negative impact on QoL compared to T1DM. Mode of treatment further stratifies QoL decline for HNF1A-MODY subjects.

Indexed as

AdultBody Mass IndexDiabetes Mellitus, Type 2FemaleGerminal Center KinasesHepatocyte Nuclear Factor 1-alphaHumansHypoglycemic AgentsMaleMiddle AgedMutationQuality of LifeYoung AdultGerminal Center KinasesHepatocyte Nuclear Factor 1-alphaHypoglycemic AgentsMAP4K2 protein, humanDiabetesMODYQuality of life

Identifiers

PMID30421137
PMCPMC6531383
OpenAlexW2901523996

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.