Evidence map›Paper›PMID 30421129›Full record

ArticleMolecular biology reports2019

Expression of TLR4-PTGE2 signaling genes in atherosclerotic carotid plaques and peripheral blood.

S Ferronato, A Scuro, S Fochi, E Orlandi, M Gomez-Lira, S Olivato, S Mazzucco, A Turco, M G Romanelli

Abstract read
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In one paragraph

Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

S FerronatoSection of Biology and Genetics, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.ORCID http://orcid.org/0000-0003-1103-3089
A ScuroDepartment of Surgery, Dentistry, Pediatrics and Gynaecology, Unit of Vascular and Endovascular Surgery, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0002-7986-8624
S FochiSection of Biology and Genetics, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.ORCID http://orcid.org/0000-0002-8616-5775
E OrlandiSection of Biology and Genetics, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.ORCID http://orcid.org/0000-0002-1484-4170
M Gomez-LiraSection of Biology and Genetics, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy. macarena.gomezlira@univr.it.ORCID http://orcid.org/0000-0003-4119-2267
S OlivatoSection of Neurophatology, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0002-7052-4155
S MazzuccoDepartment of Clinical Neurosciences, Centre for Prevention of Stroke and Dementia Nuffield, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-1582-6724
A TurcoSection of Biology and Genetics, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.ORCID http://orcid.org/0000-0002-3476-7694
M G RomanelliSection of Biology and Genetics, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.ORCID http://orcid.org/0000-0002-7360-1195
University of Verona · ITUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toll-like receptor 4 (TLR4)/prostaglandine synthetase 2 (PTGS2) signaling plays a relevant role in atherosclerotic plaque vulnerability. The purpose of this study was to check the gene expression of 6 genes participating to TLR4/PTGS2 signaling (TLR4, PTGS2, ACSL4, PTGER3, PTGER4, and EPRAP) in carotid plaques and blood samples from the same individual and to evaluate these genes as biomarker of plaque progression. We investigated differential gene expression by qRT-PCR in 62 atherosclerotic patients' carotid plaques and corresponding blood sample. A very weak or no correlation was observed in the overall population or analyzing asymptomatic patients. These analyzed genes are most likely not suitable for inclusion in the clinical routine as biomarkers of plaque instability.

Indexed as

Gene Expression RegulationSignal TransductionAgedCarotid ArteriesCyclooxygenase 2FemaleHumansMalePlaque, AtheroscleroticToll-Like Receptor 4Cyclooxygenase 2PTGS2 protein, humanToll-Like Receptor 4AtherosclerosisBlood and plaquesGene expression

Identifiers

PMID30421129
OpenAlexW2901156306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.