Evidence map›Paper›PMID 30421112›Full record

ArticleVirologica Sinica2018

In Vitro Anti-hepatitis B Virus Activity of 2',3'-Dideoxyguanosine.

Pinghu Zhang, Shuo Zhai, Jinhong Chang, Ju-Tao Guo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virologica Sinica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Pinghu ZhangInstitute of Translational Medicine and Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou, 225001, China.ORCID http://orcid.org/0000-0002-7600-4740
Shuo ZhaiInstitute of Translational Medicine and Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou, 225001, China.
Jinhong ChangBaruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, PA, 18902, USA.
Ju-Tao GuoBaruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, PA, 18902, USA. ju-tao.guo@bblumberg.org.ORCID http://orcid.org/0000-0001-5335-2788
Hepatitis B Foundation · USQinghai University · CNYangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

2',3'-dideoxyguanosine (DoG) has been demonstrated to inhibit duck hepatitis B virus (DHBV) replication in vivo in a duck model of HBV infection. In the current study, the in vitro antiviral effects of DoG on human and animal hepadnaviruses were investigated. Our results showed that DoG effectively inhibited HBV, DHBV, and woodchuck hepatitis virus (WHV) replication in hepatocyte-derived cells in a dose-dependent manner, with 50% effective concentrations (EC

Indexed as

AnimalsAntiviral AgentsCell LineDideoxynucleosidesHepatitis B virusHepatitis B Virus, DuckHepatitis B Virus, WoodchuckHepatocytesHumansNucleic Acid Synthesis InhibitorsNucleosidesRNA, ViralVirus Replication2',3'-dideoxyguanosineAntiviral AgentsDideoxynucleosidesNucleic Acid Synthesis InhibitorsNucleosidesRNA, ViralAntiviralHBVHepatitis BNucleoside analoguesWoodchuck hepatitis virus (WHV)

Identifiers

PMID30421112
PMCPMC6335223
OpenAlexW2900944688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.