Evidence map›Paper›PMID 30421007›Full record

ArticleEuropean journal of applied physiology2019

Limb blood flow and tissue perfusion during exercise with blood flow restriction.

Matthew A Kilgas, John McDaniel, Jon Stavres, Brandon S Pollock, Tyler J Singer, Steven J Elmer

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Article in European journal of applied physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Prognostic value of exercise blood pressure: role of fitness and exercise training.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Tourniquet cuff pressure during blood flow restriction exercise.Frontiers in sports and active living · 2025
    Article
  11. Article
  12. Article
  13. Regional Differences in Skeletal Muscle OAdvances in experimental medicine and biology · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Effects of Blood Flow Restriction on OFrontiers in physiology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matthew A KilgasDepartment of Kinesiology and Integrative Physiology, College of Science and Arts, Michigan Technological University, 1400 Townsend Dr, Houghton, MI, 49931, USA.
John McDanielDepartment of Exercise Physiology, Kent State University, Kent, OH, USA.
Jon StavresDepartment of Exercise Physiology, Kent State University, Kent, OH, USA.
Brandon S PollockDepartment of Exercise Physiology, Kent State University, Kent, OH, USA.
Tyler J SingerDepartment of Exercise Physiology, Kent State University, Kent, OH, USA.
Steven J ElmerDepartment of Kinesiology and Integrative Physiology, College of Science and Arts, Michigan Technological University, 1400 Townsend Dr, Houghton, MI, 49931, USA. sjelmer@mtu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionExercise with blood flow restriction (BFR) is emerging as an effective modality for improving muscular function in clinical and athletic populations. Selection of cuff pressure is critical because it should maximize metabolic stress without completely occluding blood flow or compromising user safety. It is unknown how cuff pressures determined at rest influence blood flow hemodynamics during exercise. PURPOSE: We evaluated changes in blood flow and tissue perfusion before, during, and after exercise with BFR.

methodsTen males performed rhythmic handgrip exercise (30 contractions, 30% MVC) at 0%, 60%, 80%, 100%, and 120% of limb occlusion pressure (LOP). Brachial artery blood flow and tissue saturation were assessed using Doppler ultrasound and near-infrared spectroscopy, respectively.

resultsAt rest blood flow generally decreased with increased pressure (0% > 60% ≈ 80% > 100% ≈ 120% LOP). During 60% and 80% LOP conditions, blood flow increased during exercise from rest and decreased after exercise (all P < 0.05). Compared to 0% LOP, relative blood flow at 60% and 80% LOP decreased by 22-47% at rest, 22-48% during exercise, and 52-71% after exercise (all P < 0.05). Increased LOP decreased tissue saturation during exercise with BFR (P < 0.05). Heart rate, mean arterial pressure, and cardiac output did not differ across LOP.

conclusionAt pressures below LOP the cardiovascular system overcame the external pressure and increased blood flow to exercising muscles. Relative reductions in blood flow at rest were similar to those during exercise. Thus, the relative occlusion measured at rest approximated the degree of occlusion during exercise. Moderate cuff pressures increased metabolic stress without completely occluding blood flow.

Indexed as

AdultBlood PressureBrachial ArteryExerciseForearmHand StrengthHemodynamicsHumansMaleMuscle, SkeletalPressureRegional Blood FlowResistance TrainingTourniquetsYoung AdultArterial blood flowFunctional near inferred spectroscopyHandgrip exerciseKaatsuResistance exerciseVascular occlusion

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.