Evidence map›Paper›PMID 30420858›Full record

ArticleFrontiers in immunology2018

Baseline Circulating Activated TFH and Tissue-Like Exhausted B Cells Negatively Correlate With Meningococcal C Conjugate Vaccine Induced Antibodies in HIV-Infected Individuals.

Lucimar Milagres, Giselle Silva, Wânia Pereira-Manfro, Ana Cristina Frota, Cristina Hofer, Bianca Ferreira, Daniela Barreto, Marcelo Figueredo, Barbara Coelho, Lucia Villela and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Lucimar MilagresDepartment of Microbiology Immunology and Parasitology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Giselle SilvaDepartment of Microbiology Immunology and Parasitology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Wânia Pereira-ManfroDepartment of Microbiology Immunology and Parasitology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Ana Cristina FrotaDepartment of Pediatrics, Instituto de Puericultura e Pediatria Martagão Gesteira, Rio de Janeiro, Brazil.
Cristina HoferDepartment of Pediatrics, Instituto de Puericultura e Pediatria Martagão Gesteira, Rio de Janeiro, Brazil.
Bianca FerreiraDepartment of Pediatrics, Instituto de Puericultura e Pediatria Martagão Gesteira, Rio de Janeiro, Brazil.
Daniela BarretoDepartment of Pediatrics, Instituto de Puericultura e Pediatria Martagão Gesteira, Rio de Janeiro, Brazil.
Marcelo FigueredoDepartment of Periodontics, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Barbara CoelhoDepartment of Periodontics, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Lucia VillelaLaboratory of Immunology, Pedro Ernesto University Hospital, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Constantinos PetrovasImmunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, MD, United States.
Richard KoupImmunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, MD, United States.
Universidade do Estado do Rio de Janeiro · BRNational Institutes of Health · USHospital Universitário Pedro Ernesto · BRUniversidade Federal do Rio de Janeiro · BR

Funding

Tfh and B cells in HIV/SIV pathogenesis and vaccinationZIAAI005015 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KOUP, RICHARD A · 2009 to 2025
$24.1M
Testing of Blood Samples for Immune Response and Vaccine ResearchZIAAI005073 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KOUP, RICHARD A · 2009 to 2025
$23.4M
HIV/SIV Replication In VivoZIAAI005014 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KOUP, RICHARD A · 2009 to 2025
$22.7M
Immunogenicity of meningococcal C conjugate vaccine in HIV infected childrenR01TW008397 · FIC · FEDERAL UNIVERSITY OF RIO DE JANEIRO · PI HOFER, CRISTINA BARROSO · 2009 to 2013
$250k
FIC NIH HHS R01 TW008397
6 · The paper itself

Abstract

Since 2006, meningococcal serogroup C (MenC) conjugate (MCC) vaccines have been supplied by the Brazilian government for HIV-infected children under 13 years old. For measuring protection against MenC, the serum bactericidal antibody (SBA) assay is the method of choice. The characterization of T follicular helper cells (TFH) cells has been an area of intensive study because of their significance in multiple human diseases and in vaccinology. The objective of this study was to characterize the phenotype of peripheral TFH cells and B cells and how they associated with each other and with SBA levels induced by vaccination as well as with serum cytokine levels of HIV-infected and non-infected children and adolescents. We found that CD27

Indexed as

AdolescentAntibodies, BacterialBlood CirculationB-LymphocytesChildChild, PreschoolCohort StudiesDisease ResistanceFemaleGerminal CenterHIV-1HIV InfectionsHumansInterleukin-4Lymphocyte ActivationMaleAntibodies, BacterialInterleukin-4Meningococcal Vaccinesserogroup C meningococcal conjugate vaccinebactericidal antibodiesexhausted B cellsHIV infectionmeningococcal vaccinesT follicular helper cells

Identifiers

PMID30420858
PMCPMC6215828
OpenAlexW2899319424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.