Evidence map›Paper›PMID 30420785›Full record

ArticleNature microbiology2019

Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility.

Corina Beerli, Artur Yakimovich, Samuel Kilcher, Glennys V Reynoso, Gotthold Fläschner, Daniel J Müller, Heather D Hickman, Jason Mercer

Open access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 100 citations in OpenAlex.

  1. Article
  2. Review
  3. Cytomegalovirus disrupts Lamin A/C to control microtubule-mediated nuclear movement and cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Exploring 4,7-Disubstituted Pyrimido[4,5-Molecules (Basel, Switzerland) · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. A comprehensive review of monkeypox virus and mpox characteristics.Frontiers in cellular and infection microbiology · 2024
    Review
  20. Mpox (formerly monkeypox): pathogenesis, prevention, and treatment.Signal transduction and targeted therapy · 2023
    Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Corina BeerliMRC Laboratory for Molecular Cell Biology, University College London, London, UK.
Artur YakimovichMRC Laboratory for Molecular Cell Biology, University College London, London, UK.
Samuel KilcherMRC Laboratory for Molecular Cell Biology, University College London, London, UK.ORCID http://orcid.org/0000-0002-1162-6549
Glennys V ReynosoViral Immunity and Pathogenesis Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Gotthold FläschnerDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.ORCID http://orcid.org/0000-0001-6707-6905
Daniel J MüllerDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Heather D HickmanViral Immunity and Pathogenesis Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Jason MercerMRC Laboratory for Molecular Cell Biology, University College London, London, UK. jason.mercer@ucl.ac.uk.ORCID http://orcid.org/0000-0003-1466-9541
ETH Zurich · CHMRC Laboratory for Molecular Cell Biology · GBNational Institutes of Health · US

Funding

Imaging Antiviral ImmunityZIAAI001225 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HICKMAN, HEATHER · 2017 to 2025
$11.4M
Medical Research Council MC_UU_00012/7Medical Research Council MC_UU_12018/7
6 · The paper itself

Abstract

Cell motility is essential for viral dissemination

Indexed as

Cell MovementHost-Pathogen InteractionsSignal TransductionADAM10 ProteinAmyloid Precursor Protein SecretasesAnimalsCell LineCytopathogenic Effect, ViralEnzyme InhibitorsErbB ReceptorsGene DeletionHeLa CellsHumansIntercellular Signaling Peptides and ProteinsMembrane ProteinsMiceADAM10 ProteinADAM10 protein, humanAmyloid Precursor Protein SecretasesEGFR protein, humanEnzyme InhibitorsErbB ReceptorsF11L protein, vaccinia virusIntercellular Signaling Peptides and ProteinsMembrane ProteinsPeptidesvaccinia growth factorViral Proteins

Identifiers

PMID30420785
PMCPMC6354922
OpenAlexW2900255325

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.