ArticleNature microbiology2019
Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity.
Abstract readLetter
In one paragraph
Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
What it found
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Who cites it
107 citing papers in PubMed, 142 citations in OpenAlex.
- Structure of full-length APOBEC3B bound to EBV BORF2 reveals coordinated neutralization of a cancer-associated mutator.Research square · 2026Article
- Article
- Full-length structure of the anti-viral and pro-tumor DNA deaminase APOBEC3B.bioRxiv : the preprint server for biology · 2026Article
- KSHV Genome in Saliva, Whole Blood and Kaposi's Sarcoma Biopsy Specimens in Republic of Congo: Phylogenetic Analysis and an APOBEC3B Mutational Signature.Journal of medical virology · 2026Article
- A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B.Nature communications · 2026Article
- Exon Targeted Retrieval and Classification Toolbox (ExTRaCT): a gene search pipeline to find APOBEC3 Z-domains in novel bat genomes.bioRxiv : the preprint server for biology · 2026Article
- Herpes simplex virus type 1 R-loops are targets for APOBEC-mediated mutagenesis.Genome biology · 2026Article
- Analysis of the APOBEC3 footprint across the Anelloviridae family.Archives of virology · 2026Article
- Article
- HAMMER: hairpin-based APOBEC3A-mediated mRNA editing reporter.Nucleic acids research · 2026Article
- APOBEC3B regulates HPV replication by inducing R-loop formation and DNA damage.PLoS pathogens · 2026Article
- HAMMER: Hairpin-based APOBEC3A-mediated mRNA editing reporter.bioRxiv : the preprint server for biology · 2026Article
- Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity.Nature communications · 2026Article
- Article
- RNase H-sensitive accumulation of APOBEC3B in a nucleolus after DNA damage.Bioscience reports · 2025Article
- Identification of Epstein-Barr virus BORF2 sequences required for APOBEC3B relocalization.Journal of virology · 2025Article
- Article
- Kaposi's sarcoma-associated herpesvirus ORF61 protein sequesters APOBEC3B in filamentous aggregates.Journal of virology · 2025Article
- Herpes simplex virus 1 evades APOBEC1-mediated immunity via its uracil-DNA glycosylase in mice.Nature microbiology · 2025Article
- HHV-6B ribonucleotide reductase sequesters NF-κB subunit p65 to inhibit innate immune responses.iScience · 2025Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Adam Z ChengDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-6277-9433
Jaime Yockteng-MelgarDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Matthew C JarvisDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Natasha Malik-SoniDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Ivan BorozanOntario Institute for Cancer Research, MaRS Centre, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-3145-3550
Michael A CarpenterDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Jennifer L McCannDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Diako EbrahimiDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-8577-0420
Nadine M ShabanDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Edyta MarconDonnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Jack GreenblattDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
William L BrownDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-5354-9468
Lori FrappierDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. lori.frappier@utoronto.ca.ORCID http://orcid.org/0000-0003-0110-5472
Reuben S HarrisDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. rsh@umn.edu.ORCID http://orcid.org/0000-0002-9034-9112
University of Minnesota · USUniversity of Toronto · CAOntario Institute for Cancer Research · CA
Funding
X-ray Crystallographic Fragment Screening CoreU54AI150472 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI LYUMKIS, DMITRY · 2019 to 2021
$15.7MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008244 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SHIMIZU, YOJI · 1988 to 2024
$13.6MTRAINING GRANT IN MICROBIOLOGY/CANCER RESEARCHT32CA009138 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Scott M. Dehm · 1985 to 2026
$11.3MX-ray Crystallographic Fragment Screening CoreU54GM103368 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SARAFIANOS, STEFAN G, TORBETT, BRUCE EDWARD · 2017 to 2018
$11.1MMolecular Determinants of HIV hypermutationR21AI138793 · NIAID · UNIVERSITY OF MINNESOTA · PI EBRAHIMI, DIAKO · 2018 to 2019
$470k(PQ2) HIV INFECTION, APOBEC UPREGULATION, AND CANCER MUTAGENESISR21CA206309 · NCI · UNIVERSITY OF MINNESOTA · PI HARRIS, REUBEN S · 2016 to 2017
$401kHIV-1 Vif in AIDS-Related MalignanciesF30CA200432 · NCI · UNIVERSITY OF MINNESOTA · PI CHENG, ADAM Z · 2015 to 2019
$213kHoward Hughes Medical InstituteNCI NIH HHS F30 CA200432NCI NIH HHS R21 CA206309NCI NIH HHS T32 CA009138NIAID NIH HHS R21 AI138793NIGMS NIH HHS T32 GM008244NIGMS NIH HHS U54 GM103368
Abstract
The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like (APOBEC) family of single-stranded DNA (ssDNA) cytosine deaminases provides innate immunity against virus and transposon replication
Indexed as
Catalytic DomainCell LineCRISPR-Cas SystemsCytidine DeaminaseGenome, ViralHEK293 CellsHerpesvirus 4, HumanHerpesvirus 8, HumanHumansMinor Histocompatibility AntigensRibonucleotide ReductasesRNA InterferenceRNA, Small InterferingViral ProteinsAPOBEC3B protein, humanCytidine DeaminaseMinor Histocompatibility AntigensRibonucleotide ReductasesRNA, Small InterferingViral Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.