Evidence map›Paper›PMID 30420773›Full record

ReviewNature structural & molecular biology2018

RNA motifs and combinatorial prediction of interactions, stability and localization of noncoding RNAs.

Minakshi Gandhi, Maiwen Caudron-Herger, Sven Diederichs

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature structural & molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Minakshi GandhiDivision of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-9813-9638
Maiwen Caudron-HergerDivision of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sven DiederichsDivision of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. s.diederichs@dkfz.de.ORCID http://orcid.org/0000-0001-7901-4752

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the number of documented noncoding RNAs (ncRNAs) is rapidly increasing, knowledge of their molecular function is lagging behind. The identification of specific RNA motifs that mediate transcript stability, interactions and localization may aid in the prediction of these features in new transcripts and may have potential implications for ncRNA function. Here, we review RNA motifs, focusing on four recent studies identifying nuclear-retention motifs, and discuss the limited specificity of short-RNA motifs and the resulting challenge for effective functional prediction. Future approaches may succeed by integrating combinatorial and cooperative effects of additional partially sequence-based properties.

Indexed as

Nucleotide MotifsModels, MolecularRNA StabilityRNA, UntranslatedRNA, Untranslated

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.