ArticleNature communications2018
Structural insights into the function of type VI secretion system TssA subunits.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Functional diversity of accessory factors of the type VI secretion system.Journal of bacteriology · 2026Review
- Initial identification of genomic islands in Taylorella equigenitalis and Taylorella asinigenitalis and their distribution in isolates from around the world.BMC microbiology · 2026Article
- Review
- The multifunctional type VI secretion system ofApplied and environmental microbiology · 2025Review
- The Competitive Edge: T6SS-Mediated Interference Competition byMicroorganisms · 2025Review
- Functionality of chimeric TssA proteins in the type VI secretion system reveals sheath docking specificity within their N-terminal domains.Nature communications · 2024Article
- Identification of a system for hydroxamate xenosiderophore-mediated iron transport inMicrobiology (Reading, England) · 2024Article
- Distribution and diversity of type VI secretion system clusters inMicrobial genomics · 2023Article
- Killing in the name of: T6SS structure and effector diversity.Microbiology (Reading, England) · 2023Review
- ThebioRxiv : the preprint server for biology · 2023Article
- The type-VI secretion system of the beneficial symbiontMicrobiology (Reading, England) · 2023Review
- Uncovering the Secretion Systems ofAntibiotics (Basel, Switzerland) · 2023Review
- The Biological and Regulatory Role of Type VI Secretion System ofInfection and drug resistance · 2023Review
- The Bradyrhizobium Sp. LmicA16 Type VI Secretion System Is Required for Efficient Nodulation of Lupinus Spp.Microbial ecology · 2022Article
- Molecular architecture of bacterial type IV secretion systems.PLoS pathogens · 2022Review
- Structure of a type IV secretion system core complex encoded by multi-drug resistance F plasmids.Nature communications · 2022Article
- Article
- A novel stabilization mechanism for the type VI secretion system sheath.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Identification and Characterization of EvpQ, a Novel T6SS Effector Encoded on a Mobile Genetic Element inFrontiers in microbiology · 2021Article
- Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The type VI secretion system (T6SS) is a multi-protein complex that injects bacterial effector proteins into target cells. It is composed of a cell membrane complex anchored to a contractile bacteriophage tail-like apparatus consisting of a sharpened tube that is ejected by the contraction of a sheath against a baseplate. We present structural and biochemical studies on TssA subunits from two different T6SSs that reveal radically different quaternary structures in comparison to the dodecameric E. coli TssA that arise from differences in their C-terminal sequences. Despite this, the different TssAs retain equivalent interactions with other components of the complex and position their highly conserved N-terminal ImpA_N domain at the same radius from the centre of the sheath as a result of their distinct domain architectures, which includes additional spacer domains and highly mobile interdomain linkers. Together, these variations allow these distinct TssAs to perform a similar function in the complex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.