ArticleNature neuroscience2018
Neuronal stability in medial frontal cortex sets individual variability in decision-making.
Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Fluctuation-learning relationship in recurrent neural networks.Nature communications · 2025Article
- Direct and indirect striatal projecting neurons exert strategy-dependent effects on decision-making.Science advances · 2025Article
- Stability and robustness of idiosyncratic choice bias.Communications psychology · 2025Article
- Adrenergic Modulation of Cortical Gain and Sensory Processing in the Mouse Visual Cortex.Brain sciences · 2025Article
- Article
- Single-Trial Representations of Decision-Related Variables by Decomposed Frontal Corticostriatal Ensemble Activity.eNeuro · 2024Article
- Disentangling the role of NAc D1 and D2 cells in hedonic eating.Molecular psychiatry · 2023Article
- Cognition and the single neuron: How cell types construct the dynamic computations of frontal cortex.Current opinion in neurobiology · 2022Review
- The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands.Neuroscience and biobehavioral reviews · 2022Review
- Hearing, touching, and multisensory integration during mate choice.Frontiers in neural circuits · 2022Review
- Concomitant Processing of Choice and Outcome in Frontal Corticostriatal Ensembles Correlates with Performance of Rats.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Multiple-Timescale Neural Networks: Generation of History-Dependent Sequences and Inference Through Autonomous Bifurcations.Frontiers in computational neuroscience · 2021Article
- Secondary motor cortex: Broadcasting and biasing animal's decisions through long-range circuits.International review of neurobiology · 2021Review
- Harnessing behavioral diversity to understand neural computations for cognition.Current opinion in neurobiology · 2019Review
- The neural computation of inconsistent choice behavior.Nature communications · 2019Article
- Same lesson, varied choices by frontal cortex.Nature neuroscience · 2018Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the brain, decision making is instantiated in dedicated neural circuits. However, there is considerable individual variability in decision-making behavior, particularly under uncertainty. The origins of decision variability within these conserved neural circuits are not known. Here we demonstrate in the rat medial frontal cortex (MFC) that individual variability is a consequence of altered stability in neuronal populations. In a sensory-guided choice task, rats trained on familiar stimuli were exposed to unfamiliar stimuli, resulting in variable choice responses across individuals. We created a recurrent network model to examine the source of variability in MFC neurons, and found that the landscape of neural population trajectories explained choice variability across different unfamiliar stimuli. We experimentally confirmed model predictions showing that trial-by-trial variability in neuronal activity indexes the landscape and predicts individual variation. These results show that neural stability is a critical component of the MFC neural dynamics that underpins individual variation in decision-making.
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