Evidence map›Paper›PMID 30420708›Full record

ArticlePediatric research2019

Abnormalities in autonomic function in obese boys at-risk for insulin resistance and obstructive sleep apnea.

Flavia M S Oliveira, Winston H Tran, Daniel J Lesser, Rajeev Bhatia, Thomas G Keens, Steven D Mittelman, Sally L Davidson Ward, Michael C K Khoo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Comparison of WatchPAT to polysomnography measurement of apnea-hypopnea index and obstructive sleep apnea severity in adolescents with overweight and obesity.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Flavia M S OliveiraDepartment of Electrical Engineering, University of Brasilia, Brasilia, Brazil. flavia@ene.unb.br.
Winston H TranDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Daniel J LesserDivision of Pediatric Pulmonology and Sleep Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Rajeev BhatiaDivision of Pediatric Pulmonology and Sleep Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Thomas G KeensDivision of Pediatric Pulmonology and Sleep Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Steven D MittelmanDiabetes & Obesity Program, Center for Endocrinology, Diabetes & Metabolism, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Sally L Davidson WardDivision of Pediatric Pulmonology and Sleep Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Michael C K KhooDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Children's Hospital of Los Angeles · USUniversity of Southern California · USUniversidade de Brasília · BR

Funding

VEGF VECTOR TO ISCHEMIC MYOCARDIUM W/DIFFUSE CORONARY DISEASEM01RR000047 · NCRR · WEILL MEDICAL COLL OF CORNELL UNIV · PI WARD, MARY J · 1985 to 2007
$36.4M
TrainingP41EB001978 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KHOO, MICHAEL C K · 2003 to 2017
$18.1M
USC Center for Transdisciplinary Research on Energetics*U54CA116848 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GORAN, MICHAEL ISAAC · 2005 to 2010
$12.1M
Model-based Phenotyping of OSAS in Pediatric Obesity using Dynamic MR ImagingR01HL105210 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KHOO, MICHAEL C K · 2010 to 2013
$3.4M
Markers of Autonomic and Metabolic Control in Childhood ObesityR21HL090451 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KHOO, MICHAEL C K · 2007 to 2009
$1.1M
NCI NIH HHS U54 CA116848NCRR NIH HHS M01 RR000047NHLBI NIH HHS R01 HL105210NHLBI NIH HHS R21 HL090451NIBIB NIH HHS P41 EB001978
6 · The paper itself

Abstract

STUDY

objectivesCurrent evidence in adults suggests that, independent of obesity, obstructive sleep apnea (OSA) can lead to autonomic dysfunction and impaired glucose metabolism, but these relationships are less clear in children. The purpose of this study was to investigate the associations among OSA, glucose metabolism, and daytime autonomic function in obese pediatric subjects.

methodsTwenty-three obese boys participated in: overnight polysomnography; a frequently sampled intravenous glucose tolerance test; and recordings of spontaneous cardiorespiratory data in both the supine (baseline) and standing (sympathetic stimulus) postures.

resultsBaseline systolic blood pressure and reactivity of low-frequency heart rate variability to postural stress correlated with insulin resistance, increased fasting glucose, and reduced beta-cell function, but not OSA severity. Baroreflex sensitivity reactivity was reduced with sleep fragmentation, but only for subjects with low insulin sensitivity and/or low first-phase insulin response to glucose.

conclusionsThese findings suggest that vascular sympathetic activity impairment is more strongly affected by metabolic dysfunction than by OSA severity, while blunted vagal autonomic function associated with sleep fragmentation in OSA is enhanced when metabolic dysfunction is also present.

Indexed as

AdolescentAutonomic Nervous SystemBaroreflexBlood GlucoseBlood PressureChildHeart RateHumansInsulin ResistanceMaleModels, NeurologicalObesityRisk FactorsSleep Apnea, ObstructiveVagus NerveBlood Glucose

Identifiers

PMID30420708
PMCPMC6494692
OpenAlexW2901801402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.