ArticlePediatric research2019
Maternal obesity and offspring cognition: the role of inflammation.
Article in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Trial
- Trial
- Maternal obesity induces activator protein 1-mediated inflammatory response to impair embryonic neurogenesis.The Journal of physiology · 2026Article
- Neurodevelopmental Pathways from Maternal Obesity to Offspring Outcomes: An Umbrella Review of Cognitive and Behavioral Consequences Across Development.Healthcare (Basel, Switzerland) · 2025Review
- Gestational vitamin D concentration and child cognitive development: a longitudinal cohort study in the Environmental influences on Child Health Outcomes Program.The American journal of clinical nutrition · 2025Article
- Gestational Age and Cognitive Development in Childhood.JAMA network open · 2025Article
- The Impact of the Exposome on Alzheimer's Disease: The Influence of Nutrition.International journal of molecular sciences · 2025Review
- Maternal Prepregnancy Obesity and Offspring Intelligence Quotient at 5 Years: A Multicohort Analysis.Paediatric and perinatal epidemiology · 2025Article
- Pre-pregnancy body mass index and offspring neurobehavioral development: a birth cohort study.Frontiers in nutrition · 2025Article
- The role of nutrition and gut microbiome in childhood brain development and behavior.Frontiers in nutrition · 2025Review
- Maternal Gut Microbiome-Mediated Epigenetic Modifications in Cognitive Development and Impairments: A New Frontier for Therapeutic Innovation.Nutrients · 2024Review
- Placental inflammatory cytokines mRNA expression and preschool children's cognitive performance: a birth cohort study in China.BMC medicine · 2023Article
- Associations between the human immune system and gut microbiome with neurodevelopment in the first 5 years of life: A systematic scoping review.Developmental psychobiology · 2023Article
- Maternal Inflammatory Biomarkers during Pregnancy and Early Life Neurodevelopment in Offspring: Results from the VDAART Study.International journal of molecular sciences · 2022Article
- Maternal Pre-Pregnancy Body Mass Index, Gestational Weight Gain and Children's Cognitive Development: A Birth Cohort Study.Nutrients · 2022Article
- Fetal programming of human energy homeostasis brain networks: Issues and considerations.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification.Scientific reports · 2021Observational
- Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer's disease.Alzheimer's research & therapy · 2021Article
- Review
- Fetal brain and placental programming in maternal obesity: A review of human and animal model studies.Prenatal diagnosis · 2020Review
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHigh pre-pregnancy body mass index (ppBMI) has been linked to neurodevelopmental impairments in childhood. However, very few studies have investigated mechanisms in human cohorts.
methodsAmong 1361 mother-child pairs in Project Viva, we examined associations of ppBMI categories with the Peabody Picture Vocabulary Test III [PPVT] and Wide Range Assessment of Visual Motor Abilities [WRAVMA] in early childhood (median 3.2y); and with the Kaufman Brief Intelligence test (KBIT) and WRAVMA in mid-childhood (7.7y). We further examined the role of maternal inflammation in these associations using the following measures from the 2nd trimester of pregnancy: plasma C-reactive protein (CRP), dietary inflammatory index (DII), and plasma omega-6 (n-6): n-3 fatty acid ratio.
resultsChildren of mothers with prenatal obesity (ppBMI ≥30 kg/m
conclusionMaternal inflammation may modestly mediate the association between maternal obesity and offspring visual motor abilities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.