ArticleEuropean journal of human genetics : EJHG2019
Mendelian randomization reveals unexpected effects of CETP on the lipoprotein profile.
Article in European journal of human genetics : EJHG, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease.Nature communications · 2021Pooled it
- Trial
- High-density lipoprotein: a biomarker and therapeutic target in sepsis.Critical care (London, England) · 2025Review
- Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis.Circulation research · 2024Article
- CETP inhibition enhances monocyte activation and bacterial clearance and reduces streptococcus pneumonia-associated mortality in mice.JCI insight · 2024Article
- Association between human blood metabolome and the risk of pre-eclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Synthesis, Molecular Modeling and Biological Evaluation of Novel Trifluoromethyl Benzamides as Promising CETP Inhibitors.Current computer-aided drug design · 2024Article
- A PolynesianHGG advances · 2023Article
- [Gene polymorphisms of cytochrome B-245 alpha chain (Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
- Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.PLoS biology · 2022Article
- Article
- Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target.Metabolites · 2021Review
- Review
- Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study.Scientific reports · 2020Article
- Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans.Hepatology (Baltimore, Md.) · 2020Article
- Correction: Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.PLoS biology · 2020Article
- Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol.Brain : a journal of neurology · 2020Article
- Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to the current dogma, cholesteryl ester transfer protein (CETP) decreases high-density lipoprotein (HDL)-cholesterol (C) and increases low-density lipoprotein (LDL)-C. However, detailed insight into the effects of CETP on lipoprotein subclasses is lacking. Therefore, we used a Mendelian randomization approach based on a genetic score for serum CETP concentration (rs247616, rs12720922 and rs1968905) to estimate causal effects per unit (µg/mL) increase in CETP on 159 standardized metabolic biomarkers, primarily lipoprotein subclasses. Metabolic biomarkers were measured by nuclear magnetic resonance (NMR) in 5672 participants of the Netherlands Epidemiology of Obesity (NEO) study. Higher CETP concentrations were associated with less large HDL (largest effect XL-HDL-C, P = 6 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.