ArticleNature immunology2018
TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4
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Article in Nature immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
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Who cites it
44 citing papers in PubMed, 64 citations in OpenAlex.
- WDR12 Promotes Glucose Metabolism via PFKFB4 Upregulation in Gastric Cancer.Cancer science · 2026Article
- Single-cell transcriptomics reveals diversity and conservation of chicken lymphocytes.Poultry science · 2026Article
- Article
- Transcriptional regulation of Ligase IV by an intronic regulatory element directs thymocyte development.Genes and immunity · 2025Article
- Article
- Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate.Science immunology · 2025Article
- The epigenetic landscape of fate decisions in T cells.Nature immunology · 2025Review
- TOX, through a glass, darkly.Frontiers in immunology · 2025Review
- Identification of co-localised transcription factors based on paired motifs analysis.IET systems biology · 2024Article
- TCF1 dosage determines cell fate during T cell development.Science advances · 2024Article
- Stabilization of β-Catenin Directs HEB to Limit Thymic Selection.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- The multifaceted roles of TCF1 in innate and adaptive lymphocytes.Advances in immunology · 2024Review
- Intrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity.Nature immunology · 2023Article
- The 3D enhancer network of the developing T cell genome is shaped by SATB1.Nature communications · 2022Article
- Tcf12 is required to sustain myogenic genes synergism with MyoD by remodelling the chromatin landscape.Communications biology · 2022Article
- Tcf-1 promotes genomic instability and T cell transformation in response to aberrant β-catenin activation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8Nature immunology · 2022Article
- TCF-1 mediates chromatin intermingling during T cell development.Nature immunology · 2022Article
- TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors.Nature immunology · 2022Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Akinola Olumide EmmanuelDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Stephen ArnovitzDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Leila HaghiDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Priya S MathurDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Soumi MondalDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Jasmin QuandtDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Michael K OkoreehDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Mark Maienschein-ClineCore for Research Informatics, University of Illinois at Chicago, Chicago, IL, USA.
Khashayarsha KhazaieDepartment of Immunology, Department of Surgery, Mayo Clinic, Rochester, MN, USA.
Marei DoseDepartment of Medicine, University of Chicago, Chicago, IL, USA. mareidose0@gmail.com.ORCID http://orcid.org/0000-0001-5394-9779
Fotini GounariDepartment of Medicine, University of Chicago, Chicago, IL, USA. fgounari@uchicago.edu.ORCID http://orcid.org/0000-0003-2936-066X
University of Chicago · USMayo Clinic in Arizona · USUniversity of Illinois Chicago · US
Funding
Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7MULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8MRESEARCH TRAINING IN RESPIRATORY BIOLOGYT32HL007605 · NHLBI · UNIVERSITY OF CHICAGO · PI Yun Fang, Gokhan M. Mutlu · 1985 to 2026
$18.1MRuth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)T32HD007009 · NICHD · UNIVERSITY OF CHICAGO · PI NANCY B SCHWARTZ · 1985 to 2026
$13.0MMulti-Disciplinary Training Grant in Cancer ResearchT32CA009594 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD, Scott A. Oakes · 1989 to 2026
$11.5MSpatio-Temporal Organization of Chromatin and Information Transfer in CancerU54CA193419 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LICHT, JONATHAN D., O'HALLORAN, THOMAS V · 2015 to 2020
$10.4MHow beta-catenin expands Foxp3+RORgammat+ Pro-inflammatoryT-regulatory cells - RenewalR01AI108682 · NIAID · UNIVERSITY OF CHICAGO · PI GOUNARI, FOTINI, KHAZAIE, KHASHAYARSHA · 2014 to 2024
$5.1MProinflammatory T Regulatory Cells in Colon CancerR01CA160436 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KHAZAIE, KHASHAYARSHA · 2012 to 2017
$2.0MSignaling in the DN to DP thymocyte transitionR01AI059676 · NIAID · UNIVERSITY OF CHICAGO · PI GOUNARI, FOTINI · 2004 to 2008
$1.8MWnt/b-catenin signaling in T-cell transformationR21AI076720 · NIAID · UNIVERSITY OF CHICAGO · PI GOUNARI, FOTINI · 2008 to 2009
$422kNCATS NIH HHS UL1 TR002003NCI NIH HHS R01 CA160436NCI NIH HHS T32 CA009594NHLBI NIH HHS T32 HL007605NIAID NIH HHS R01 AI059676NIAID NIH HHS R01 AI108682NIAID NIH HHS R21 AI076720NICHD NIH HHS T32 HD007009NIDDK NIH HHS P30 DK042086NIH HHS R01AI108682NIH HHS R01CA160436NIH HHS R21AI076720NIH HHS U54CA193419NIH HHS UL1TR002003
Abstract
Thymocyte development requires a complex orchestration of multiple transcription factors. Ablating either TCF-1 or HEB in CD4
Indexed as
AnimalsBasic Helix-Loop-Helix ProteinsCD4 AntigensCD8 AntigensGene Expression RegulationHepatocyte Nuclear Factor 1-alphaLymphopoiesisMiceMice, Inbred C57BLMice, TransgenicThymocytesBasic Helix-Loop-Helix ProteinsCD4 AntigensCD8 AntigensHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseTcf12 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.