Evidence map›Paper›PMID 30420606›Full record

ArticleNature2018

The entropic force generated by intrinsically disordered segments tunes protein function.

Nicholas D Keul, Krishnadev Oruganty, Elizabeth T Schaper Bergman, Nathaniel R Beattie, Weston E McDonald, Renuka Kadirvelraj, Michael L Gross, Robert S Phillips, Stephen C Harvey, Zachary A Wood

Abstract read
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 151 citations in OpenAlex.

  1. Interlayer rotation (twisting) switches interlayer mobility in moiré superlattices.Proceedings of the National Academy of Sciences of the United States of America · 2026
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Nicholas D KeulDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Krishnadev OrugantyDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Elizabeth T Schaper BergmanDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO, USA.
Nathaniel R BeattieDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Weston E McDonaldDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Renuka KadirvelrajDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Michael L GrossDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO, USA.
Robert S PhillipsDepartment of Chemistry, University of Georgia, Athens, GA, USA.
Stephen C HarveyDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
Zachary A WoodDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA. zaw@uga.edu.
University of Georgia · USWashington University in St. Louis · USUniversity of Michigan–Ann Arbor · USUniversity of Pennsylvania · US

Funding

TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
The role of intrinsic disorder in the allosteric regulation of human UGDHR01GM114298 · NIGMS · UNIVERSITY OF GEORGIA · PI WOOD, ZACHARY ARTHUR · 2015 to 2025
$2.7M
NIGMS NIH HHS P41 GM103422NIGMS NIH HHS R01 GM114298
6 · The paper itself

Abstract

Protein structures are dynamic and can explore a large conformational landscape

Indexed as

EntropyEvolution, MolecularAllosteric RegulationAmino Acid SequenceHumansIntrinsically Disordered ProteinsModels, MolecularPeptide FragmentsProtein ConformationProtein FoldingProtein UnfoldingProteomeSubstrate SpecificityUridine Diphosphate Glucose DehydrogenaseIntrinsically Disordered ProteinsPeptide FragmentsProteomeUridine Diphosphate Glucose Dehydrogenase

Identifiers

PMID30420606
PMCPMC6415545
OpenAlexW2900324446

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.