Evidence map›Paper›PMID 30420498›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Mutations in

Allison R Demas, Aabha I Sharma, Wesley Wong, Angela M Early, Seth Redmond, Selina Bopp, Daniel E Neafsey, Sarah K Volkman, Daniel L Hartl, Dyann F Wirth

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
17.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 166 citations in OpenAlex.

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  18. Review
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  20. A NovelmedRxiv : the preprint server for health sciences · 2025
    Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Allison R DemasDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115.
Aabha I SharmaDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115.
Wesley WongDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115.
Angela M EarlyInfectious Disease and Microbiome Program, Broad Institute, Cambridge, MA 02142.
Seth RedmondInfectious Disease and Microbiome Program, Broad Institute, Cambridge, MA 02142.
Selina BoppDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115.
Daniel E NeafseyDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115.
Sarah K VolkmanDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115.
Daniel L HartlDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115; dhartl@oeb.harvard.edu dfwirth@hsph.harvard.edu.
Dyann F WirthDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115; dhartl@oeb.harvard.edu dfwirth@hsph.harvard.edu.ORCID 0000-0002-8604-4455
Broad Institute · USHarvard University · US

Funding

Novel Genetic Mechanism of Artemisinin Resistance for MalariaR01AI099105 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI HARTL, DANIEL L, WIRTH, DYANN F · 2013 to 2021
$5.4M
NIAID NIH HHS R01 AI099105
6 · The paper itself

Abstract

Drug resistance is an obstacle to global malaria control, as evidenced by the recent emergence and rapid spread of delayed artemisinin (ART) clearance by mutant forms of the

Indexed as

4-ButyrolactoneAcetogeninsAntimalarialsArtemisininsClustered Regularly Interspaced Short Palindromic RepeatsDrug ResistanceGene EditingHumansMalaria, FalciparumMicrofilament ProteinsMutationPlasmodium falciparumWD40 Repeats4-ButyrolactoneAcetogeninsAntimalarialsArtemisininsartenimolcoronin acetogeninMicrofilament Proteinsactinartemisinin resistancecoroninevolutionmalaria

Identifiers

PMID30420498
PMCPMC6294886
OpenAlexW2900669172

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.