ArticlePsychological medicine2019
The roles of early-life adversity and rumination in neural response to emotional faces amongst anxious and depressed adults.
Article in Psychological medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Adverse Life Experiences and Brain Function: A Meta-Analysis of Functional Magnetic Resonance Imaging Findings.JAMA network open · 2023Pooled it
- The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis.British journal of anaesthesia · 2023Pooled it
- Emotion Recognition in Adults With a History of Childhood Maltreatment: A Systematic Review.Trauma, violence & abuse · 2023Pooled it
- Correction of Reward Processing Deficits in Youth with Disruptive Behavior and Trauma Exposure: A Pilot Study of Neural Responses to Fluoxetine.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Electroencephalogram Gamma Band Power Correlates with Anhedonia in a Community Sample.Journal of personalized medicine · 2025Article
- Brain White Matter Alterations in Young Adults with Childhood Emotional Neglect Experience.Behavioral sciences (Basel, Switzerland) · 2025Article
- Exploring the Role of Empathy in the Association Between Early Life Adversity and Antisocial Behavior.Affective science · 2025Article
- Early threat experiences relate to reduced neural face discrimination in youth with emerging psychiatric symptoms: a frequency-tagging electroencephalography study.Social cognitive and affective neuroscience · 2025Article
- Early Life Stress and Major Depressive Disorder-An Update on Molecular Mechanisms and Synaptic Impairments.Molecular neurobiology · 2024Review
- Impacts of age and environment on postnatal microglial activity: Consequences for cognitive function following early life adversity.PloS one · 2024Article
- The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology.Stress (Amsterdam, Netherlands) · 2024Review
- The influence of childhood emotional neglect experience on brain dynamic functional connectivity in young adults.European journal of psychotraumatology · 2023Article
- The relationship between childhood emotional neglect experience and depressive symptoms and prefrontal resting functional connections in college students: The mediating role of reappraisal strategy.Frontiers in behavioral neuroscience · 2023Article
- Article
- Neural functional connectivity during rumination in individuals with adverse childhood experiences.European journal of psychotraumatology · 2022Article
- Mindfulness-Based Cognitive Therapy in Recurrent MDD Patients With Residual Symptoms: Alterations in Resting-State Theta Oscillation Dynamics Associated With Changes in Depression and Rumination.Frontiers in psychiatry · 2022Article
- Disrupted Spatiotemporal Complexity of Resting-State Electroencephalogram Dynamics Is Associated With Adaptive and Maladaptive Rumination in Major Depressive Disorder.Frontiers in neuroscience · 2022Article
- Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework.Neuroscience and biobehavioral reviews · 2021Review
- Childhood maltreatment results in altered deactivation of reward processing circuits in depressed patients: A functional magnetic resonance imaging study of a facial emotion recognition task.Neurobiology of stress · 2021Article
- Early Life Adversity as a Moderator of Symptom Change following Selective Serotonin Reuptake Inhibitors and Cognitive Behavioral Therapy.Cognitive therapy and research · 2021Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundEarly-life adversity (ELA) is a risk factor for internalizing psychopathology (IP). ELA is also linked to alterations in neural phenotypes of emotion processing and maladaptive emotion regulatory strategies, such as ruminative brooding, in adulthood. We therefore expected that ELA would predict cortical brain activation to emotional faces in transdiagnostic IP and in turn, mediate the extent of rumination amongst patients with IPs and ELA (IP + ELA).
methodOne hundred and thirty-two individuals, including 102 treatment-seeking adults with heterogeneous IPs and 30 healthy controls (HCs) performed an Emotional Face-Matching Task during functional magnetic resonance imaging. Whole-brain analyses compared HC (n = 30), IP (n = 52), and IP + ELA (n = 50) neural responses to emotional (angry, fearful, happy, and sad) faces v. shapes, controlling for depression and anxiety symptoms. Parameter estimates of activation were extracted for significant between-group differences and tested as a mediator of ruminative brooding in IP + ELA.
resultsIP + ELA demonstrated increased activation in the superior frontal gyrus and anterior cingulate cortex (fear), superior parietal lobule, precuneus, posterior cingulate, and inferior temporal gyrus (fear only), and cuneus (fear and angry). These regions were preferentially correlated with ruminative brooding in IP + ELA, many of which mediated the link between IP + ELA and ruminative brooding.
conclusionsResults provide evidence that ELA history amongst IP patients augments engagement of brain regions involved in emotion processing, above and beyond what is accounted for by current symptoms. Though longitudinal designs are needed, alterations in the neural correlates of maladaptive processing of socio-emotional information may be a common pathway by which ELA poses risk for psychopathology.
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