Trial reportJournal of neuroengineering and rehabilitation2018
Effect of high-frequency alternating current transcutaneous stimulation over muscle strength: a controlled pilot study.
Trial report in Journal of neuroengineering and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Peripheral Nerve Conduction Block Using a High Frequency Alternating Stimulation: A Pilot Study
Effectiveness and Safety of Electrical Stimulation With Alternating High-frequency Currents (30-50 Kilohertz) on the Sensorimotor System in Healthy Volunteer Subjects
Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Transcutaneous electrical nerve inhibition using medium frequency alternating current.Scientific reports · 2022Trial
- 20-kHz alternating current stimulation: effects on motor and somatosensory thresholds.Journal of neuroengineering and rehabilitation · 2020Trial
- Flexible multichannel muscle impedance sensors for collaborative human-machine interfaces.Science advances · 2025Article
- Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson's Disease: A Double-Blind, Randomized, Crossover Study.Journal of clinical medicine · 2024Article
- Kilohertz-frequency interferential current induces hypoalgesic effects more comfortably than TENS.Scientific reports · 2023Article
- Effect of percutaneous electrical stimulation with high-frequency alternating currents at 30 kHz on the sensory-motor system.Frontiers in neuroscience · 2023Article
- Effect of Percutaneous Electric Stimulation with High-Frequency Alternating Currents on the Sensory-Motor System of Healthy Volunteers: A Double-Blind Randomized Controlled Study.Journal of clinical medicine · 2022Article
- Review
- Transcutaneous high-frequency alternating current for rapid reversible muscle force reduction below pain threshold.Journal of neural engineering · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh-frequency alternating currents of greater than 1 kHz applied on peripheral nerves has been used in animal studies to produce a motor nerve block. It has been evidenced that frequencies higher than 5 kHz are necessary to produce a complete peripheral nerve block in primates, whose nerve thickness is more similar to humans. The aim of the study was to determine the effect on muscle strength after the application of a high-frequency stimulation at 5 and 10 kHz compared to sham stimulation in healthy volunteers.
findingsTranscutaneous stimulation at 5 kHz, 10 kHz and sham stimulation were applied to eleven healthy volunteers over the ulnar and median nerves for 20 min. Maximal handgrip strength was measured before, during, immediately after the intervention, and 10 min after the end of intervention. The 10 kHz stimulation showed a lower handgrip strength during the intervention (28.1 N, SEM 3.9) when compared to 5 kHz (31.1 N, SEM 3.6; p < 0.001) and to sham stimulation (33.7 N, SEM 3.9; p < 0.001). Furthermore, only stimulation at 10 kHz decreased handgrip strength when compared to baseline.
conclusionsThese findings suggest high-frequency stimulation has an inhibitory effect over muscle strength. Future studies are required in patients that are characterized by motor hyperactive such as spasticity or tremors. CLINICAL
trial registrationNCT, NCT03169049 . Registered on 30 May 2017.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.