ArticleBMC veterinary research2018
Protective immunity induced by Eimeria common antigen 14-3-3 against Eimeria tenella, Eimeria acervulina and Eimeria maxima.
Article in BMC veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
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- UnderstandingFrontiers in cellular and infection microbiology · 2026Review
- Mechanism of Qingchang compound against coccidiosis based on network pharmacology-molecular docking.Frontiers in veterinary science · 2024Article
- Protective Efficacy Induced by the CommonVaccines · 2023Article
- Effect of anAnimals : an open access journal from MDPI · 2023Article
- Protective efficacy of multiepitope vaccines constructed from common antigens of Eimeria species in chickens.Veterinary research · 2023Article
- Assessment of the Immunoprotective Efficacy of Recombinant 14-3-3 Protein and Dense Granule Protein 10 (GRA10) as Candidate Antigens for Rabbit Vaccines againstInternational journal of molecular sciences · 2023Article
- Evaluation of gene expression related to immunity, apoptosis, and gut integrity that underlies3 Biotech · 2023Article
- Vaccines against chicken coccidiosis with particular reference to previous decade: progress, challenges, and opportunities.Parasitology research · 2022Review
- Influence of Insoluble Dietary Fibre on Expression of Pro-Inflammatory Marker Genes in Caecum, Ileal Morphology, Performance, and Foot Pad Dermatitis in Broiler.Animals : an open access journal from MDPI · 2022Article
- Em14-3-3 delivered by PLGA and chitosan nanoparticles conferred improved protection in chicken against Eimeria maxima.Parasitology research · 2022Article
- Designing multiepitope-based vaccine against Eimeria from immune mapped protein 1 (IMP-1) antigen using immunoinformatic approach.Scientific reports · 2021Article
- Rhomboid protein 2 of Eimeria maxima provided partial protection against infection by homologous species.Veterinary research · 2021Article
- Understanding the interactions between Eimeria infection and gut microbiota, towards the control of chicken coccidiosis: a review.Parasite (Paris, France) · 2021Review
- Protective Efficacy of Rhomboid-Like Protein 3 as a Candidate Antigen AgainstFrontiers in microbiology · 2021Article
- The effect of a Local isolate and Houghton strain ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020Article
- Immunoproteomic and mass spectrometric analysis of Eimeria acervulina antigens recognized by antisera from chickens infected with E. acervulina, E. tenella or E. necatrix.Parasites & vectors · 2020Article
- Molecular characterization of a potential receptor of Eimeria acervulina microneme protein 3 from chicken duodenal epithelial cells.Parasite (Paris, France) · 2020Article
- Modulations of genes related to gut integrity, apoptosis, and immunity underlie the beneficial effects ofJournal of animal science and biotechnology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAvian coccidiosis is often caused by co-infection with several species of Eimeria worldwide. Developing a multivalent vaccine with an antigen common to multiple Eimeria species is a promising strategy for controlling clinical common co-infection of Eimeria. In the previous study, 14-3-3 was identified as one of the immunogenic common antigen in E. tenella, E. acervulina and E. maxima. The aim of the present study was to evaluate the immunogenicity and protective efficacy of Ea14-3-3 in the form of DNA vaccine against infection with three species of Eimeria both individually and simultaneously.
resultsAfter vaccination with pVAX-Ea14-3-3, the Ea14-3-3 gene was transcribed and expressed in the injected muscles. Vaccination with pVAX-Ea14-3-3 significantly increased the proportion of CD4
conclusionThese results indicate that Ea14-3-3 is highly immunogenic and capable to induce significant immune responses. Furthermore, Ea14-3-3 antigen can provide effective protection against infection with Eimeria tenella, Eimeria acervulina, Eimeria maxima both individually and in combination with three Eimeria species. Significant outcomes of our study provide an effective candidate antigen for developing a multivalent Eimeria vaccine against mixed infection with various Eimeria species under natural conditions.
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