SynthesisBMC ophthalmology2018
Association between diabetic retinopathy in type 2 diabetes and the ICAM-1 rs5498 polymorphism: a meta-analysis of case-control studies.
Synthesis in BMC ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Association of ICAM-1 Gene Polymorphisms with Diabetic Retinopathy in T2DM Patients from Northern India: Case-control and meta-analysis.World journal of diabetes · 2025Article
- Precision Medicine for Diabetic Retinopathy: Integrating Genetics, Biomarkers, Lifestyle, and AI.Genes · 2025Review
- Inflammation: The Link between Neural and Vascular Impairment in the Diabetic Retina and Therapeutic Implications.International journal of molecular sciences · 2023Review
- Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling.Cell biology and toxicology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic studies have reported contradictory results on the association between the intercellular adhesion molecule-1 (ICAM-1) rs5498 polymorphism and diabetic retinopathy (DR) risk in type 2 diabetic patients. We aimed to perform a systematic literature search and conduct random-effects meta-analysis to provide a quantitative evaluation.
methodsWe searched Pubmed, Embase, Scopus, Web of Science and Wanfang databases from inception up to January 2018. Allelic and genotype frequencies of rs5498 was compared between DR cases and controls. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using a random effects model.
resultsNine studies involving a total of 1792 cases and 1400 controls met our inclusion criteria. We did not find any significant association between rs5498 and DR risk at the dominant model (GG + GA versus AA, OR = 1.00, 95% CI: 0.66-1.50, P = 0.987), the recessive model (GG versus GA + AA, OR = 1.24, 95% CI: 0.86-1.77, P = 0.245), the GG versus AA contrast (OR = 1.14, 95% CI: 0.68-1.92, P = 0.611), and the G allele versus A allele contrast (OR = 1.08, 95% CI: 0.81-1.45, P = 0.592). Subgroup analysis by ethnicity showed no association in Asian populations (G allele versus A allele: OR = 1.05, 95% CI: 0.76-1.44, P = 0.790). Subgroup analysis by DR subtype also did not reveal any association of rs5498 with proliferative DR (G allele versus A allele: OR = 1.34, 95% CI: 0.71-2.52, P = 0.364) and non-proliferative DR (G allele versus A allele: OR = 0.71, 95% CI: 0.43-1.17, P = 0.180).
conclusionOur meta-analyses provide no evidence of the association of rs5498 with DR in type 2 diabetic patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.