ArticleBMC geriatrics2018
The pace and prognosis of peripheral sensory loss in advanced age: association with gait speed and falls.
Article in BMC geriatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Beyond strength: dietary nitrate augments self-selected functional mobility after resistance training in middle-aged adults.GeroScience · 2026Trial
- Beyond gait speed: a multidimensional motor signature of motoric cognitive risk syndrome identified through domain-specific anomaly detection.GeroScience · 2026Article
- "Foot and Ankle Risk Factors for Future Falls in Older Adults: A Systematic Review With Meta-Analysis of Prospective Cohort Studies".Health science reports · 2026Review
- Mechanistic Pathways Linking Type 2 Diabetes Mellitus, Hypertension, and Osteoarthritis to Falls in Older Adults: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- Vitamin B12 Deficiency Presenting as Anemia and Functional Decline in an Older Adult: A Case Report.Cureus · 2026Article
- Sensory processing impairments and their associations with physical and psychological outcomes in older adults after fall-related hip fracture surgery: a prospective cross-sectional study.BMC geriatrics · 2026Observational
- What determines gait speed in community-living older adults? A relative weight analysis.European geriatric medicine · 2025Article
- Resting-State Functional Connectivity of Sensorimotor and Default Mode Networks and Lower Limb Performance in Chronic Stroke: A Cross-Sectional Study.Brain and behavior · 2025Article
- Associations between dual-task walking and cognitive impairment in people attending a cognitive diagnostic clinic.Australasian journal on ageing · 2025Article
- Aging-associated sensory decline and Alzheimer's disease.Molecular neurodegeneration · 2024Review
- Peripheral neuropathy, gait speed, and lower extremity function in community-dwelling older adults with and without diabetes.Journal of the American Geriatrics Society · 2024Article
- The prediction model of fall risk for the elderly based on gait analysis.BMC public health · 2024Article
- Exploring Shared Effects of Multisensory Impairment, Physical Dysfunction, and Cognitive Impairment on Physical Activity: An Observational Study in a National Sample.Journal of aging and physical activity · 2022Observational
- Somatosensory impairment of the feet is associated with higher activation of prefrontal cortex during walking in older adults.Experimental gerontology · 2022Article
- Extended effects of a wearable sensory prosthesis on gait, balance function and falls after 26 weeks of use in persons with peripheral neuropathy and high fall risk-The walk2Wellness trial.Frontiers in aging neuroscience · 2022Article
- The Predictive Validity and Clinical Application of Stopping Elderly Accidents, Deaths & Injuries (STEADI) for Fall Risk Screening.Advances in geriatric medicine and research · 2022Article
- Six month lower-leg mechanical tactile sensory stimulation alters functional network connectivity associated with improved gait in older adults with peripheral neuropathy - A pilot study.Frontiers in aging neuroscience · 2022Article
- Risk Factors Related to Falling in Patients after Stroke.Iranian journal of public health · 2021Article
- Older People's Experiences of Living with, Responding to and Managing Sensory Loss.Healthcare (Basel, Switzerland) · 2021Article
- Diagnosis and Management of Cognitive Concerns in the Oldest-Old.Current treatment options in neurology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPeripheral sensory loss is considered one of many risk factors for gait impairments and falls in older adults, yet no prospective studies have examined changes in touch sensation in the foot over time and their relationship to mobility and falls. Therefore, we aimed to determine the prevalence and progression of peripheral sensory deficits in the feet of older adults, and whether sensory changes are associated with the slowing of gait and development of falls over 5 years.
methodsUsing baseline, and 18 and 60 month followup data from the Maintenance Of Balance, Independent Living, Intellect, and Zest in the Elderly (MOBILIZE) Study in Boston, MA, we determined changes in the ability to detect stimulation of the great toe with Semmes Weinstein monofilaments in 351 older adults. We used covariate-adjusted repeated measures analysis of variance to determine relationships between sensory changes and gait speed or fall rates.
resultsSubjects whose sensory function was consistently impaired over 5 years had a significantly steeper decline in gait speed (- 0.23 m/s; 95% CI: -0.28 to - 0.18) compared to those with consistently intact sensory function (- 0.12 m/s; 95% CI: -0.15 to - 0.08) and those progressing from intact to impaired sensory function (- 0.13 m/s; - 0.16 to - 0.10). Compared to subjects with consistently intact sensation, those whose sensory function progressed to impairment during followup had the greatest risk of falls (adjusted risk ratio = 1.57 (95% confidence interval = 1.12 to 2.22).
conclusionsOur longitudinal results indicate that a progressive decline in peripheral touch sensation is a risk factor for mobility impairment and falls in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.