Evidence map›Paper›PMID 30419760›Full record

ArticleASN neuro

An In Vitro Model of Charcot-Marie-Tooth Disease Type 4B2 Provides Insight Into the Roles of MTMR13 and MTMR2 in Schwann Cell Myelination.

Danielle C Robinson, Anna E Mammel, Anne M Logan, Aubree A Larson, Eric J Schmidt, Alec F Condon, Fred L Robinson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ASN neuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Biology open · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Danielle C Robinson1 Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA.
Anna E Mammel1 Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA.
Anne M Logan1 Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA.
Aubree A Larson1 Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA.
Eric J Schmidt1 Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA.
Alec F Condon1 Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA.
Fred L Robinson1 Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA.
Oregon Health & Science University · USCenter for Neurosciences · USVollum Institute · US

Funding

Ultrastructure and Single Particle Microscopy CoreP30NS061800 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A · 2009 to 2020
$6.6M
Myotubularin PI 3-Phosphatases as Regulators of Peripheral Nerve MyelinationR01NS086812 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROBINSON, FRED L · 2014 to 2018
$1.7M
Roles of Myotubularin PI 3-phosphatases in Demyelinating Peripheral NeuropathyR00NS057903 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROBINSON, FRED L · 2009 to 2011
$738k
Deltavision RT Image Restoration System for Established Research Core FacilityS10RR023432 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLER, THOMAS J · 2007 to 2007
$365k
Roles of Myotubularin PI 3-phosphatases in Demyelinating Peripheral NeuropathyK99NS057903 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROBINSON, FRED L · 2007 to 2008
$167k
NCRR NIH HHS S10 RR023432NINDS NIH HHS K99 NS057903NINDS NIH HHS P30 NS061800NINDS NIH HHS R00 NS057903NINDS NIH HHS R01 NS086812
6 · The paper itself

Abstract

Charcot-Marie-Tooth Disorder Type 4B (CMT4B) is a demyelinating peripheral neuropathy caused by mutations in myotubularin-related (MTMR) proteins 2, 13, or 5 (CMT4B1/2/3), which regulate phosphoinositide turnover and endosomal trafficking. Although mouse models of CMT4B2 exist, an in vitro model would make possible pharmacological and reverse genetic experiments needed to clarify the role of MTMR13 in myelination. We have generated such a model using Schwann cell-dorsal root ganglion (SC-DRG) explants from Mtmr13

Indexed as

AnimalsClass III Phosphatidylinositol 3-KinasesClass I Phosphatidylinositol 3-KinasesCoculture TechniquesDemyelinating DiseasesEmbryo, MammalianFemaleGanglia, SpinalGene Expression RegulationGreen Fluorescent ProteinsHumansMiceMice, Inbred C57BLMice, TransgenicMyelin Basic ProteinNerve Growth FactorClass III Phosphatidylinositol 3-KinasesClass I Phosphatidylinositol 3-Kinasesenhanced green fluorescent proteinGreen Fluorescent ProteinsMtmr2 protein, mouseMyelin Basic ProteinNerve Growth FactorPhosphatidylinositol 3-KinasesPIK3C3 protein, mousePik3cb protein, mouseProtein Tyrosine Phosphatases, Non-ReceptorSbf2 protein, mouseendosomal traffickingmyelinationmyotubularinphosphatidylinositide 3-kinasephosphatidylinositide 3-phosphataseSchwann cell

Identifiers

PMID30419760
PMCPMC6236487
OpenAlexW2901001386

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.