ArticleIntestinal research2019
Association of visceral adiposity and insulin resistance with colorectal adenoma and colorectal cancer.
Article in Intestinal research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Adiposity associations with risk of colorectal cancer: a systematic review.Obesity (Silver Spring, Md.) · 2025Pooled it
- The role of Adiponectin and Leptin in Colorectal Cancer and Adenoma: a systematic review and meta-analysis.BMC cancer · 2025Pooled it
- Association between Atherosclerosis and High-Risk Colorectal Adenomas based on Cardio-Ankle Vascular Index and Ankle-Brachial Index.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2024Article
- MAFLD with central obesity is associated with increased risk of colorectal adenoma and high-risk adenoma.BMC gastroenterology · 2024Article
- Change in abdominal obesity after colon cancer surgery - effects of left-sided and right-sided colonic resection.International journal of obesity (2005) · 2024Article
- Article
- Hot Spots and Trends in the Relationship between Cancer and Obesity: A Systematic Review and Knowledge Graph Analysis.Life (Basel, Switzerland) · 2023Review
- Relationship between BMI, CT-derived body composition and colorectal neoplasia in a bowel screening population.Scottish medical journal · 2022Article
- The Association of Waist Circumference with the Prevalence and Survival of Digestive Tract Cancer in US Adults: A Population Study Based on Machine Learning Methods.Computational and mathematical methods in medicine · 2022Article
- Obesity, sleep apnea, and cancer.International journal of obesity (2005) · 2020Review
- Changes in Abdominal Obesity Affect the Risk of Metachronous Advanced Colorectal Neoplasia Development after Polypectomy.Yonsei medical journal · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsTo examine whether visceral adiposity serves as a risk factor for colorectal cancer (CRC) and colorectal adenomas.
methodsTwo hundred healthy subjects, 200 patients with colorectal adenoma, and 151 patients with CRC (46 with early-stage and 105 with advanced-stage cancers) were enrolled at a tertiary referral hospital. All subjects underwent colonoscopy, and had laboratory data, and computed tomography (CT) scan available for abdominal fat measurement. An abdominal CT scan taken 1 to 4 years (mean interval, 20.6 months) before the diagnosis of CRC was also available in the 42 CRC patients.
resultsThe mean areas of visceral adipose tissue (VAT) areas in the control, adenoma, early- and advanced-stage CRC groups were 94.6, 116.8, 110.4, and 99.7 cm2 , respectively (P<0.001). The risk of adenoma positively correlated with VAT area and the visceral-to-total fat ratio (P for trend <0.01), but the risk of CRC did not (P>0.05). The risk of both adenoma and CRC positively correlated with fasting plasma glucose levels (P for trend <0.05). In patients with early-stage cancer (n=17), VAT area decreased when the CT scan at diagnosis was compared with that taken before the diagnosis of CRC, but superficial adipose tissue area did not, so visceral-to-total fat ratio significantly decreased (46.6% vs. 50.7%, respectively, P=0.018).
conclusionsVAT area is related to the risk of colorectal adenoma. However, VAT decreases from the early stages of CRC. Impaired fasting glucose has a role in colorectal carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.