Evidence map›Paper›PMID 30419540›Full record

ArticleTranslational oncology2019

Multi-Spectral Fluorescence Imaging of Colon Dysplasia InVivo Using a Multi-Spectral Endoscopy System.

Sang Mun Bae, Dong-Jun Bae, Eun-Ju Do, Gyungseok Oh, Su Woong Yoo, Gil-Je Lee, Ji Soo Chae, Youngkuk Yun, Sungjee Kim, Ki Hean Kim and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 1 country.

Sang Mun BaeAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea; Department of Medicine, University of Ulsan College of Medicine, Seoul 138-736, South Korea.
Dong-Jun BaeAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea.
Eun-Ju DoAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea.
Gyungseok OhSchool of Mechanical Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, South Korea.
Su Woong YooDepartment of Biomedical Science and Engineering, Institute of Integrated Technology (IIT), Gwangju, Institute of Science and Technology, Gwangju 61005, South Korea.
Gil-Je LeeDiscovery and Analytic Solution, PerkinElmer Korea, Seoul 08380, South Korea.
Ji Soo ChaeDiscovery and Analytic Solution, PerkinElmer Korea, Seoul 08380, South Korea.
Youngkuk YunDiscovery and Analytic Solution, PerkinElmer Korea, Seoul 08380, South Korea.
Sungjee KimDepartment of Chemistry, Pohang University of Science and Technology, Pohang 790-784, South Korea.
Ki Hean KimDepartment of Mechanical Engineering, Pohang University of Science and Technology, Pohang 790-784, South Korea.
Euiheon ChungSchool of Mechanical Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, South Korea; Department of Biomedical Science and Engineering, Institute of Integrated Technology (IIT), Gwangju, Institute of Science and Technology, Gwangju 61005, South Korea.
Jun Ki KimBiomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea.
Sung Wook HwangDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea.
Sang Hyoung ParkDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea.
Dong-Hoon YangDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea.
Byong Duk YeDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea.
Jeong-Sik ByeonDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea.
Suk-Kyun YangDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea.
Jinmyoung JooBiomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea; Department of Gastroenterology and Convergence Medicine, University of Ulsan College of Medicine, Seoul 138-736, South Korea.
Sang-Yeob KimAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea; Department of Gastroenterology and Convergence Medicine, University of Ulsan College of Medicine, Seoul 138-736, South Korea. Electronic address: sykim3yk@amc.seoul.kr.
Seung-Jae MyungAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea; Department of Gastroenterology and Convergence Medicine, University of Ulsan College of Medicine, Seoul 138-736, South Korea. Electronic address: sjmyung@amc.seoul.kr.
Asan Medical Center · KRGwangju Institute of Science and Technology · KRUniversity of Ulsan · KRPohang University of Science and Technology · KRUlsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND STUDY

aimTo develop a molecular imaging endoscopic system that eliminates tissue autofluorescence and distinguishes multiple fluorescent markers specifically on the cancerous lesions.

methodsNewly developed multi-spectral fluorescence endoscope device has the potential to eliminate signal interference due to autofluorescence and multiplex fluorophores in fluorescent probes. The multiplexing capability of the multi-spectral endoscope device was demonstrated in the phantom studies and multi-spectral imaging with endoscopy and macroscopy was performed to analyze fluorescence signals after administration of fluorescent probe that targets cancer in the colon. Because of the limitations in the clinical application using rigid-type small animal endoscope, we developed a flexible channel insert-type fluorescence endoscope, which was validated on the colonoscopy of dummy and porcine model.

resultsWe measured multiple fluorescent signals simultaneously, and the fluorescence spectra were unmixed to separate the fluorescent signals of each probe, in which multiple fluorescent probes clearly revealed spectral deconvolution at the specific targeting area in the mouse colon. The positive area of fluorescence signal for each probe over the whole polyp was segmented with analyzing software, and showed distinctive patterns and significantly distinguishable values: 0.46 ± 0.04, 0.39 ± 0.08 and 0.73 ± 0.12 for HMRG, CET-553 and TRA-675 probes, respectively. The spectral unmixing was finally demonstrated in the dummy and porcine model, corroborating the targeted multi-spectral fluorescence imaging of colon dysplasia.

conclusionThe multi-spectral endoscopy system may allow endoscopists to clearly identify cancerous lesion that has different patterns of various target expression using multiple fluorescent probes.

Identifiers

PMID30419540
PMCPMC6231290
OpenAlexW2900010696

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.