ArticleJournal of biomedical materials research. Part B, Applied biomaterials2019
Polymeric ionically conductive composite matrices and electrical stimulation strategies for nerve regeneration: In vitro characterization.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
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Who cites it
12 citing papers in PubMed.
- Carbon Nanodot-enabled Fluorescent Nerve Conduits for Peripheral Nerve Repair: A Systematic Review of Translational Readiness.Plastic and reconstructive surgery. Global open · 2026Article
- Scar-reducing ionically conductive chitosan bandage: Combining ionic and electrical stimulation for optimal wound healing.Biomaterials · 2026Article
- Facial nerve pathology: emerging strategies for regeneration and functional restoration.Journal of materials chemistry. B · 2025Review
- 3D Bioprinted Neural Tissues: Emerging Strategies for Regeneration and Disease Modeling.Pharmaceutics · 2025Review
- Synergistic effects of electrical and chemical cues with biodegradable scaffolds for large peripheral nerve defect regeneration.Bioactive materials · 2025Article
- Innovative spiral nerve conduits: Addressing nutrient transport and cellular activity for critical-sized nerve defects.Bioactive materials · 2025Article
- Advancements in stimulation therapies for peripheral nerve regeneration.Biomedical materials (Bristol, England) · 2024Review
- Complex Material Properties of Gel-Amin: A Transparent and Ionically Conductive Hydrogel for Neural Tissue Engineering.Cells, tissues, organs · 2023Article
- New approach to prepare cytocompatible 3D scaffolds via the combination of sodium hyaluronate and colloidal particles of conductive polymers.Scientific reports · 2022Article
- Engineering Tissues of the Central Nervous System: Interfacing Conductive Biomaterials with Neural Stem/Progenitor Cells.Advanced healthcare materials · 2022Review
- P2Y2 Receptor Mediated Neuronal Regeneration and Angiogenesis to Affect Functional Recovery in Rats with Spinal Cord Injury.Neural plasticity · 2022Article
- Bioactive polymeric materials and electrical stimulation strategies for musculoskeletal tissue repair and regeneration.Bioactive materials · 2020Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Stem cell strategies and the use of electrical stimulation (ES) represent promising new frontiers for peripheral nerve regeneration. Composite matrices were fabricated by coating electrospun polycaprolactone/cellulose acetate micro-nanofibers with chitosan and ionically conductive (IC) polymers including, sulfonated polyaniline, and lignin sulfonate. These composite matrices were characterized for surface morphology, coating uniformity, ionic conductivity, and mechanical strength to explore as scaffold materials for nerve regeneration in conjunction with ES. Composite matrices measured conductivity in the range of 0.0049-0.0068 mS/m due to the uniform coating of sulfonated polymers on the micro-nanofibers. Thin films (2D) and composite fiber matrices (3D) of IC polymers seeded with human mesenchymal stem cells (hMSCs) were electrically stimulated at 0.5 V, 20 Hz for 1 h daily for 14 days to study the changes in cell viability, morphology, and expression of the neuronal-like phenotype. In vitro ES lead to changes in hMSCs' fibroblast morphology into elongated neurite-like structures with cell bodies for ES-treated and positive control growth factor-treated groups. Immunofluorescent staining revealed the presence of neuronal markers including β3-tubulin, microtubule-associated protein 2, and nestin in response to ES. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1792-1805, 2019.
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