Evidence map›Paper›PMID 30419144›Full record

ArticleChembiochem : a European journal of chemical biology2019

Design Principles for Cationic, Astrocyte-Targeted Probes.

Alyssa N Preston, Joshua D Farr, Kevin C Tan, Danielle A Cervasio, Lauren R Butkus, Scott T Laughlin

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Blood-brain-barrier permeable fluorescent astrocyte probes.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alyssa N PrestonDepartment of Chemistry, Stony Brook University, 100 Nicolls Road, Stony Brook, NY, 11794, USA.
Joshua D FarrDepartment of Chemistry, Stanford University, 450 Serra Mall, Stanford, CA, 94305, USA.
Kevin C TanDepartment of Chemistry, Stony Brook University, 100 Nicolls Road, Stony Brook, NY, 11794, USA.
Danielle A CervasioDepartment of Chemistry, Stony Brook University, 100 Nicolls Road, Stony Brook, NY, 11794, USA.
Lauren R ButkusDepartment of Chemistry, Stony Brook University, 100 Nicolls Road, Stony Brook, NY, 11794, USA.
Scott T LaughlinDepartment of Chemistry, Stony Brook University, 100 Nicolls Road, Stony Brook, NY, 11794, USA.ORCID 0000-0002-9134-1200

Funding

Training Program in Pharmacological SciencesT32GM007518 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI GARCIA-DIAZ, MIGUEL · 1985 to 2021
$5.4M
SBU Chemistry-Biology Interface Training ProgramT32GM092714 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI SAMPSON, NICOLE S, TONGE, PETER J · 2010 to 2019
$1.7M
NIGMS NIH HHS T32 GM007518NIGMS NIH HHS T32 GM092714
6 · The paper itself

Abstract

The brain's astrocytes play key roles in normal and pathological brain processes. Targeting small molecules to astrocytes in the presence of the many other cell types in the brain will provide useful tools for their visualization and manipulation. Herein, we explore the functional consequences of synthetic modifications to a recently described astrocyte marker composed of a bright rhodamine-based fluorophore and an astrocyte-targeting moiety. We altered the nature of the targeting moiety to probe the dependence of astrocyte targeting on hydrophobicity, charge, and pK

Indexed as

AnimalsAstrocytesCerebral CortexMiceMolecular ProbesNeuronsOptical ImagingRhodaminesMolecular ProbesRhodaminesastrocytescationic fluorophoresfluorescent probesglia imagingneuroimaging

Identifiers

PMID30419144
PMCPMC6367030

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.