ArticlePloS one2018
The cut-off values of surrogate measures for insulin resistance in the Korean population according to the Korean Genome and Epidemiology Study (KOGES).
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Diagnostic and prognostic value of triglyceride glucose index: a comprehensive evaluation of meta-analysis.Cardiovascular diabetology · 2024Pooled it
- Brief Report: Improvement in Metabolic Health Parameters at Week 48 After Switching From a Tenofovir Alafenamide-Based 3- or 4-Drug Regimen to the 2-Drug Regimen of Dolutegravir/Lamivudine: The TANGO Study.Journal of acquired immune deficiency syndromes (1999) · 2021Trial
- Restricted cubic spline analysis of the association between the third-trimester triglyceride-glucose index and neonatal birthweight in pregnant women with gestational diabetes mellitus: a multicenter cohort study.BMC pregnancy and childbirth · 2026Article
- Association Between Long-Term Exposure to Particulate Matter and Glycated Hemoglobin Levels: A Cohort Study from the Korean Genome and Epidemiology Study.Journal of clinical medicine · 2026Article
- Real-World Utility of GWAS-Based Diabetes Mellitus Panel Testing.International journal of molecular sciences · 2025Article
- Identifying Cardio-Metabolic Subtypes of Prediabetes Using Latent Class Analysis.Medical sciences (Basel, Switzerland) · 2025Article
- The Genetic Variants Influencing Hypertension Prevalence Based on the Risk of Insulin Resistance as Assessed Using the Metabolic Score for Insulin Resistance (METS-IR).International journal of molecular sciences · 2024Article
- [Construction of a Predictive Model for Diabetes Mellitus Type 2 in Middle-Aged and Elderly Populations Based on the Medical Checkup Data of National Basic Public Health Service].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Article
- Surrogate indices of insulin resistance using the Matsuda index as reference in adult men-a computational approach.Frontiers in endocrinology · 2024Article
- The association of shift work and TyG index among male workers in a chemical plant of Korea: a cross-sectional study.Annals of occupational and environmental medicine · 2024Article
- Triglyceride glucose-related indexes and lipid accumulation products-reliable markers of insulin resistance in the Chinese population.Frontiers in nutrition · 2024Article
- Characteristics of insulin resistance in Korean adults from the perspective of circadian and metabolic sensing genes.Genes & genomics · 2023Article
- Association of cardiometabolic factors and insulin resistance surrogates with mortality in participants from the Korean Genome and Epidemiology Study.Lipids in health and disease · 2023Article
- Indirect Insulin Resistance Indices and Their Cut-Off Values for the Prediction of Post-Transplantation Diabetes Mellitus in Kidney Transplant Recipients.Journal of clinical medicine · 2023Article
- Inverse association of daily fermented soybean paste ("Jang") intake with metabolic syndrome risk, especially body fat and hypertension, in men of a large hospital-based cohort.Frontiers in nutrition · 2023Article
- Association of lipid accumulation product with type 2 diabetes mellitus, hypertension, and mortality: a systematic review and meta-analysis.Journal of diabetes and metabolic disorders · 2022Review
- Association between the triglyceride-glucose (TyG) index and increased blood pressure in normotensive subjects: a population-based study.Diabetology & metabolic syndrome · 2022Article
- Impact of metabolic syndrome and metabolic dysfunction-associated fatty liver disease on cardiovascular risk by the presence or absence of type 2 diabetes and according to sex.Cardiovascular diabetology · 2022Article
- Insulin Resistance Markers to Detect Nonalcoholic Fatty Liver Disease in a Male Hispanic Population.Canadian journal of gastroenterology & hepatology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe current methods available for determining insulin resistance are complicated; hence, they are only applicable to small-scale studies. Therefore, this study aimed to classify the characteristics of surrogate measures for insulin resistance and establish valid cut-off values for predicting the development of type 2 diabetes mellitus (DM) in Korean populations.
methodsThis prospective study included 7,643 participants aged 40-69 years from the Ansung-Ansan cohort database (2001-2012). Four surrogate measures, namely homeostasis model assessment-insulin resistance (HOMA-IR), visceral adiposity index (VAI), lipid accumulation product (LAP), and triglycerides and glucose (TyG) index, were analyzed. We analyzed each measure using receiver operating characteristic (ROC) curve for the development of type 2 DM. The cut-off value was determined as the value with the highest Youden index score in the specificity dominant area.
resultsThe area under the curve (AUC) was 0.566 (95% confidence interval [CI], 0.548-0.583) for HOMA-IR, 0.622 (95% CI, 0.605-0.639) for VAI, 0.642 (95% CI, 0.625-0.658) for LAP, and 0.672 (95% CI, 0.656-0.687) for TyG index. The AUC of TyG index was significantly higher than that of HOMA-IR, VAI, and LAP (p < 0.001). The cut-off value was 2.54 (sensitivity 36.8%; specificity 73.1%; hazard ratio [HR], 1.41, 95% CI, 1.25-1.59) for HOMA-IR, 2.54 (sensitivity 50.4%; specificity 68.8%; HR, 1.75, 95% CI, 1.55-1.96) for VAI, 36.6 (sensitivity 59.2%; specificity 63.9%; HR, 1.87, 95% CI, 1.64-2.14) for LAP, and 4.69 (sensitivity 62.1%; specificity 63.1%; HR, 2.17, 95% CI, 1.92-2.45) for TyG index.
conclusionsThe TyG index was a better predictor for DM than HOMA-IR. VAI and LAP showed the modest predictability for DM. The TyG index could be a useful supplementary method for identifying individuals at risk for insulin resistance and DM development.
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