Evidence map›Paper›PMID 30419029›Full record

ArticlePloS one2018

Improving counterfactual reasoning with kernelised dynamic mixing models.

Sonali Parbhoo, Omer Gottesman, Andrew Slavin Ross, Matthieu Komorowski, Aldo Faisal, Isabella Bon, Volker Roth, Finale Doshi-Velez

Abstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Preferential Mixture-of-Experts: Interpretable Models that Rely on Human Expertise As Much As Possible.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sonali ParbhooDepartment of Mathematics and Informatics, University of Basel, Basel, Switzerland.ORCID 0000-0001-8400-3732
Omer GottesmanSchool of Engineering and Applied Sciences, Harvard University, Cambridge, Massachussets, United States of America.
Andrew Slavin RossSchool of Engineering and Applied Sciences, Harvard University, Cambridge, Massachussets, United States of America.
Matthieu KomorowskiDepartment of Bioengineering, Imperial College, London, United Kingdom.
Aldo FaisalDepartment of Bioengineering, Imperial College, London, United Kingdom.
Isabella BonDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Volker RothDepartment of Mathematics and Informatics, University of Basel, Basel, Switzerland.
Finale Doshi-VelezSchool of Engineering and Applied Sciences, Harvard University, Cambridge, Massachussets, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Simulation-based approaches to disease progression allow us to make counterfactual predictions about the effects of an untried series of treatment choices. However, building accurate simulators of disease progression is challenging, limiting the utility of these approaches for real world treatment planning. In this work, we present a novel simulation-based reinforcement learning approach that mixes between models and kernel-based approaches to make its forward predictions. On two real world tasks, managing sepsis and treating HIV, we demonstrate that our approach both learns state-of-the-art treatment policies and can make accurate forward predictions about the effects of treatments on unseen patients.

Indexed as

Computer SimulationHIVHIV InfectionsHumansSepsisViral Load

Identifiers

PMID30419029
PMCPMC6231902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.