ArticlePLoS computational biology2018
Visual physiology of the layer 4 cortical circuit in silico.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 93 citations in OpenAlex.
- An in silico framework for dissecting the mechanistic origins of in vivo recorded neuronal activity.PLoS computational biology · 2026Article
- Deep-learning-assisted simulation of a cortical circuit: integrating anatomy, physiology and function.bioRxiv : the preprint server for biology · 2026Article
- The synaptic architecture of layer 5 thick tufted excitatory neurons in mouse visual cortex.Nature neuroscience · 2025Article
- Analyzing the brain's dynamic response to targeted stimulation using generative modeling.Network neuroscience (Cambridge, Mass.) · 2025Review
- Multi-scale spiking network model of human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- A comprehensive data-driven model of cat primary visual cortex.PLoS computational biology · 2024Article
- Spiking attractor model of motor cortex explains modulation of neural and behavioral variability by prior target information.Nature communications · 2024Article
- Sleep and wake in a model of the thalamocortical system with Martinotti cells.The European journal of neuroscience · 2024Article
- Multi-layered maps of neuropil with segmentation-guided contrastive learning.Nature methods · 2023Article
- Offline memory replay in recurrent neuronal networks emerges from constraints on online dynamics.The Journal of physiology · 2023Article
- Simulations of cortical networks using spatially extended conductance-based neuronal models.The Journal of physiology · 2023Review
- Article
- Cell-type-specific propagation of visual flicker.Cell reports · 2023Article
- Ultrafast simulation of large-scale neocortical microcircuitry with biophysically realistic neurons.eLife · 2022Article
- Cortical Representation of Touch in Silico.Neuroinformatics · 2022Article
- Active Dendrites and Local Field Potentials: Biophysical Mechanisms and Computational Explorations.Neuroscience · 2022Review
- Large-scale biophysically detailed model of somatosensory thalamocortical circuits in NetPyNE.Frontiers in neuroinformatics · 2022Article
- Heterogeneous Responses to Changes in Inhibitory Synaptic Strength in Networks of Spiking Neurons.Frontiers in cellular neuroscience · 2022Article
- Computational Concepts for Reconstructing and Simulating Brain Tissue.Advances in experimental medicine and biology · 2022Article
- An Anatomically Constrained Model of V1 Simple Cells Predicts the Coexistence of Push-Pull and Broad Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
Corrections and comments
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Authors and funding
30 authors at 4 institutions in 1 country.
Funding
Abstract
Despite advances in experimental techniques and accumulation of large datasets concerning the composition and properties of the cortex, quantitative modeling of cortical circuits under in-vivo-like conditions remains challenging. Here we report and publicly release a biophysically detailed circuit model of layer 4 in the mouse primary visual cortex, receiving thalamo-cortical visual inputs. The 45,000-neuron model was subjected to a battery of visual stimuli, and results were compared to published work and new in vivo experiments. Simulations reproduced a variety of observations, including effects of optogenetic perturbations. Critical to the agreement between responses in silico and in vivo were the rules of functional synaptic connectivity between neurons. Interestingly, after extreme simplification the model still performed satisfactorily on many measurements, although quantitative agreement with experiments suffered. These results emphasize the importance of functional rules of cortical wiring and enable a next generation of data-driven models of in vivo neural activity and computations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.