ArticleIEEE transactions on biomedical circuits and systems2018
Impedance Spectroscopy and Electrophysiological Imaging of Cells With a High-Density CMOS Microelectrode Array System.
Article in IEEE transactions on biomedical circuits and systems, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
- Seamless integration of CMOS microsensors into open microfluidic systems.Lab on a chip · 2025Article
- Field-Programmable Gate Array (FPGA)-Based Lock-In Amplifier System with Signal Enhancement: A Comprehensive Review on the Design for Advanced Measurement Applications.Sensors (Basel, Switzerland) · 2025Review
- Microfluidic platforms for monitoring cardiomyocyte electromechanical activity.Microsystems & nanoengineering · 2025Review
- Assessment of chemotherapeutic effects on cancer cells using adhesion noise spectroscopy.Frontiers in bioengineering and biotechnology · 2024Article
- In-Loco Optical Spectroscopy through a Multiple Digital Lock-In on a Linear Charge-Coupled Device (CCD) Array.Sensors (Basel, Switzerland) · 2023Article
- Opportunities in optical and electrical single-cell technologies to study microbial ecosystems.Frontiers in microbiology · 2023Review
- Impedance Imaging of Cells and Tissues: Design and Applications.BME frontiers · 2022Article
- Multi-parametric functional imaging of cell cultures and tissues with a CMOS microelectrode array.Lab on a chip · 2022Article
- Recent Advances in Electrical Impedance Sensing Technology for Single-Cell Analysis.Biosensors · 2021Review
- Validation of Low-Cost Impedance Analyzer via Nitrate Detection.Sensors (Basel, Switzerland) · 2021Article
- Ambipolar inverters based on cofacial vertical organic electrochemical transistor pairs for biosignal amplification.Science advances · 2021Article
- Lab-on-a-chip based mechanical actuators and sensors for single-cell and organoid culture studies.Journal of applied physics · 2021Article
- Challenges for Microelectronics in Non-Invasive Medical Diagnostics.Sensors (Basel, Switzerland) · 2020Article
- Review
- High-Density Electrical Recording and Impedance Imaging With a Multi-Modal CMOS Multi-Electrode Array Chip.Frontiers in neuroscience · 2019Article
- Technologies to Study Action Potential Propagation With a Focus on HD-MEAs.Frontiers in cellular neuroscience · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
A monolithic multi-functional CMOS microelectrode array system was developed that enables label-free electrochemical impedance spectroscopy of cells in vitro at high spatiotemporal resolution. The electrode array includes 59,760 platinum microelectrodes, densely packed within a 4.5 mm × 2.5 mm sensing region at a pitch of 13.5 μm. A total of 32 on-chip lock-in amplifiers can be used to measure the impedance of any arbitrarily chosen subset of electrodes in the array. A sinusoidal voltage, generated by an on-chip waveform generator with a frequency range from 1 Hz to 1 MHz, was applied to the reference electrode. The sensing currents through the selected recording electrodes were amplified, demodulated, filtered, and digitized to obtain the magnitude and phase information of the respective impedances. The circuitry consumes only 412 μW at 3.3 V supply voltage and occupies only 0.1 mm
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