ArticleMedical physics2019
Quantification of DNA double-strand breaks using Geant4-DNA.
Article in Medical physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Monte Carlo simulations ofMedical physics · 2026Article
- Evaluation of a new set of Geant4-DNA Physics models for the simulation of electron track structures in liquid water up to 10 MeV.Medical physics · 2026Article
- Multinomial probability model of radiation induced DSB and non-DSB clusters: tandem and bistranded damage clusters.Scientific reports · 2026Article
- In silico analysis of radiation-induced double-strand breaks by internal ex vivo irradiation of lymphocytes for 45 alpha- and beta/gamma-emitting radionuclides.EJNMMI research · 2025Article
- Radiation and DNA Origami Nanotechnology: Probing Structural Integrity at the Nanoscale.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Review
- Modeling Clustered DNA Damage by Ionizing Radiation Using Multinomial Damage Probabilities and Energy Imparted Spectra.International journal of molecular sciences · 2024Article
- DNA damage by radiation as a function of electron energy and interaction at the atomic level with Monte Carlo simulation.Zeitschrift fur medizinische Physik · 2023Article
- Simulation of DNA damage using Geant4-DNA: an overview of the "molecularDNA" example application.Precision radiation oncology · 2023Article
- Small-scale dosimetry for alpha particleEJNMMI physics · 2022Article
- Review of the Geant4-DNA Simulation Toolkit for Radiobiological Applications at the Cellular and DNA Level.Cancers · 2021Review
- Article
- Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage.Scientific reports · 2021Article
- DNA dosimeter measurements of beam profile using a novel simultaneous processing technique.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2020Article
- Ionizing Radiation and Complex DNA Damage: Quantifying the Radiobiological Damage Using Monte Carlo Simulations.Cancers · 2020Review
- Radiobiological Modeling with Monte Carlo Tools - Simulating Cellular Responses to Ionizing Radiation.Technology in cancer research & treatmentReview
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeThis study aims to standardize the simulation procedure in measuring DNA double-strand breaks (DSBs), by using advanced Monte Carlo toolkits, and newly introduced experimental methods for DNA DSB measurement.
methodsFor the experimental quantification of DNA DSB, an innovative DNA dosimeter was used to produce experimental data. GATE in combination with Geant4-DNA toolkit were exploited to simulate the experimental environment. The PDB4DNA example of Geant4-DNA was upgraded and investigated. Parameters of the simulation such energy threshold (ET) for a strand break and base pair threshold (BPT) for a DSB were evaluated, depending on the dose.
resultsSimulations resulted to minimum differentiation in comparison to experimental data for ET = 19 ± 1 eV and BPT = 10 bp, and high differentiation for ET<17.5 eV or ET>22.5 eV and BPT = 10 bp. There was also small differentiation for ET = 17.5 eV and BPT = 6 bp. Uncertainty has been kept lower than 3%.
conclusionsThis study includes first results on the quantification of DNA double-strand breaks. The energy spectrum of a LINAC was simulated and used for the first time to irradiate DNA molecules. Simulation outcome was validated on experimental data that were produced by a prototype DNA dosimeter.
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