ArticleThe Journal of clinical endocrinology and metabolism2019
Association of Plasma Vitamin D Metabolites With Incident Type 2 Diabetes: EPIC-InterAct Case-Cohort Study.
Article in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis.PLoS medicine · 2020Pooled it
- Serum Vitamin D Affected Type 2 Diabetes though Altering Lipid Profile and Modified the Effects of Testosterone on Diabetes Status.Nutrients · 2020Trial
- Potential insufficiency of vitamin D in healthy individuals: divergent performances of C3-epi-D3 levels and percentages.Scientific reports · 2026Article
- Association of 25(OH)D with general and abdominal obesity among children and adolescents in the United States: a cross-sectional NHANES analysis.BMC pediatrics · 2026Article
- Causal association of genetically determined circulating vitamin D metabolites and calcium with multiple sclerosis in participants of European descent.European journal of clinical nutrition · 2023Article
- Serum 25-hydroxyvitamin DJournal of epidemiology · 2023Article
- Phenome-wide Mendelian randomization study evaluating the association of circulating vitamin D with complex diseases.Frontiers in nutrition · 2023Review
- Article
- Vitamin D epimers are associated with circulating haemoglobin levels independently of C-reactive protein.Scientific reports · 2021Article
- Exocrine Pancreatic Dysfunction Increases the Risk of New-Onset Diabetes Mellitus: Results of a Nationwide Cohort Study.Clinical and translational science · 2021Article
- A Nonlinear Relationship Between Serum 25-Hydroxyvitamin D and Urine Albumin to Creatinine Ratio in Type 2 Diabetes: A Cross-Sectional Study in China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Vitamin D pathway-related gene polymorphisms and their association with metabolic diseases: A literature review.Journal of diabetes and metabolic disorders · 2020Review
- Serum 25 hydroxyvitamin D levels and affecting factors among preconception fertile women.BMC women's health · 2020Article
- Dyslipidemia: A Trigger for Coronary Heart Disease in Romanian Patients with Diabetes.Metabolites · 2020Article
- Vitamin D signaling maintains intestinal innate immunity and gut microbiota: potential intervention for metabolic syndrome and NAFLD.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Vitamin D release across abdominal adipose tissue in lean and obese men: The effect of ß-adrenergic stimulation.Physiological reports · 2019Article
- Vitamin D Metabolism Revised: Fall of Dogmas.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Review
- Association of Plasma Vitamin D Metabolites With Incident Type 2 Diabetes: EPIC-InterAct Case-Cohort Study.The Journal of clinical endocrinology and metabolism · 2019Article
- Vitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue.Nutrients · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors at 20 institutions in 9 countries.
Funding
Abstract
backgroundExisting evidence for the prospective association of vitamin D status with type 2 diabetes (T2D) is focused almost exclusively on circulating total 25-hydroxyvitamin D [25(OH)D] without distinction between its subtypes: nonepimeric and epimeric 25(OH)D3 stereoisomers, and 25(OH)D2, the minor component of 25(OH)D. We aimed to investigate the prospective associations of circulating levels of the sum and each of these three metabolites with incident T2D.
methodsThis analysis in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study for T2D included 9671 incident T2D cases and 13,562 subcohort members. Plasma vitamin D metabolites were quantified by liquid chromatography-mass spectrometry. We used a multivariable Prentice-weighted Cox regression to estimate hazard ratios (HRs) of T2D for each metabolite. Analyses were performed separately within country, and estimates were combined across countries using random-effects meta-analysis.
resultsThe mean concentrations (SD) of total 25(OH)D, nonepimeric 25(OH)D3, epimeric 25(OH)D3, and 25(OH)D2 were 41.1 (17.2), 40.7 (17.3), 2.13 (1.31), and 8.16 (6.52) nmol/L, respectively. Plasma total 25(OH)D and nonepimeric 25(OH)D3 were inversely associated with incident T2D [multivariable-adjusted HR per 1 SD = 0.81 (95% CI, 0.77, 0.86) for both variables], whereas epimeric 25(OH)D3 was positively associated [per 1 SD HR = 1.16 (1.09, 1.25)]. There was no statistically significant association with T2D for 25(OH)D2 [per 1 SD HR = 0.94 (0.76, 1.18)].
conclusionsPlasma nonepimeric 25(OH)D3 was inversely associated with incident T2D, consistent with it being the major metabolite contributing to total 25(OH)D. The positive association of the epimeric form of 25(OH)D3 with incident T2D provides novel information to assess the biological relevance of vitamin D epimerization and vitamin D subtypes in diabetes etiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.