ArticleThe Journal of clinical endocrinology and metabolism2019
Central Nervous System and Peripheral Hormone Responses to a Meal in Children.
Article in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hyperphagia in rare melanocortin-4 receptor pathway diseases: therapeutic options and assessing treatment response.Reviews in endocrine & metabolic disorders · 2025Pooled it
- Patterns of Children's Weight Change During Family-Based Weight Management Intervention and Associations With Outcome Through Follow-Up.Pediatric obesity · 2026Trial
- Structural and Functional Brain Changes in Children and Adolescents With Obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Defining Hyperphagia for Improved Diagnosis and Management of MC4R Pathway-Associated Disease: A Roundtable Summary.Current obesity reports · 2025Review
- Exposure to gestational diabetes mellitus in utero impacts hippocampal functional connectivity in response to food cues in children.International journal of obesity (2005) · 2024Article
- Exposure to gestational diabetes mellitus in utero impacts hippocampal functional connectivity in response to food cues in children.Research square · 2024Article
- Current Insights into the Potential Role of fMRI in Discovering the Mechanisms Underlying Obesity.Journal of clinical medicine · 2023Review
- Postprandial Increases in Liver-Gut Hormone LEAP2 Correlate with Attenuated Eating Behavior in Adults Without Obesity.Journal of the Endocrine Society · 2023Article
- Differential neural reward reactivity in response to food advertising medium in children.Frontiers in neuroscience · 2023Article
- Impaired Brain Satiety Responses After Weight Loss in Children With Obesity.The Journal of clinical endocrinology and metabolism · 2022Article
- General and Food-Specific Impulsivity and Inhibition Related to Weight Management.Childhood obesity (Print) · 2022Article
- Reassessing relationships between appetite and adiposity in people at risk of obesity: A twin study using fMRI.Physiology & behavior · 2021Article
- Strategies to Understand the Weight-Reduced State: Genetics and Brain Imaging.Obesity (Silver Spring, Md.) · 2021Review
- An Exploration of the Role of Sugar-Sweetened Beverage in Promoting Obesity and Health Disparities.Current obesity reports · 2021Review
- Modulation of neural fMRI responses to visual food cues by overeating and fasting interventions: A preliminary study.Physiological reports · 2021Article
- Child neurobiology impacts success in family-based behavioral treatment for children with obesity.International journal of obesity (2005) · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
contextBehavioral studies suggest that responses to food consumption are altered in children with obesity (OB).
objectiveTo test central nervous system and peripheral hormone response by functional MRI and satiety-regulating hormone levels before and after a meal. DESIGN AND
settingCross-sectional study comparing children with OB and children of healthy weight (HW) recruited from across the Puget Sound region of Washington.
participantsChildren (9 to 11 years old; OB, n = 54; HW, n = 22), matched for age and sex. INTERVENTION AND OUTCOME MEASURES: Neural activation to images of high- and low-calorie food and objects was evaluated across a set of a priori appetite-processing regions that included the ventral and dorsal striatum, amygdala, substantia nigra/ventral tegmental area, insula, and medial orbitofrontal cortex. Premeal and postmeal hormones (insulin, peptide YY, glucagon-like peptide-1, active ghrelin) were measured.
resultsIn response to a meal, average brain activation by high-calorie food cues vs objects in a priori regions was reduced after meals in children of HW (Z = -3.5, P < 0.0001), but not in children with OB (z = 0.28, P = 0.78) despite appropriate meal responses by gut hormones. Although premeal average brain activation by high-calorie food cues was lower in children with OB vs children of HW, postmeal activation was higher in children with OB (Z = -2.1, P = 0.04 and Z = 2.3, P = 0.02, respectively). An attenuated central response to a meal was associated with greater degree of insulin resistance.
conclusionsOur data suggest that children with OB exhibit an attenuated central, as opposed to gut hormone, response to a meal, which may predispose them to overconsumption of food or difficulty with weight loss.
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