Evidence map›Paper›PMID 30418332›Full record

ReviewJournal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society2018

The International Multiple Sclerosis Visual System Consortium: Advancing Visual System Research in Multiple Sclerosis.

Laura J Balcer, Lisanne J Balk, Alexander U Brandt, Peter A Calabresi, Elena H Martinez-Lapiscina, Rachel C Nolan, Friedemann Paul, Axel Petzold, Shiv Saidha

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laura J BalcerDepartments of Neurology, Ophthalmology & Population Health (LJ Balcer), New York University School of Medicine, New York University, New York, New York; Department of Neurology (LJ Balk, AP), Amsterdam UMC-Location VUmc, Amsterdam, the Netherlands; Department of Neurology (AUB, FP), NeuroCure Clinical Research Center and Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, Germany; Department of Neurology (PAC, SS), Johns Hopkins University, Baltimore, Maryland; Department of Neurology (EHM-L), Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; Department of Population Health (RCN), Sackler Institute for Biomedical Sciences, New York University, New York, NY, USA & Department of Neurology, New York University School of Medicine, New York University, New York, New York; and Department of Neurology (AP), University College London, the National Hospital for Neurology and Neurosurgery, Moorfields Eye Hospital, London, United Kingdom.
Lisanne J Balk
Alexander U Brandt
Peter A Calabresi
Elena H Martinez-Lapiscina
Rachel C Nolan
Friedemann Paul
Axel Petzold
Shiv Saidha

Funding

Longitudinal Assessment of Visual Function in MSR01EY014993 · NEI · UNIVERSITY OF PENNSYLVANIA · PI BALCER, LAURA · 2003 to 2007
$891k
Department of HealthNEI NIH HHS R01 EY014993
6 · The paper itself

Abstract

backgroundThe International Multiple Sclerosis Visual System Consortium (IMSVISUAL) was formed in November 2014 with the primary goal of improving research, care, and education regarding the role of the visual system in multiple sclerosis (MS) and related disorders.

methodsIn this review, we describe the formation, goals, activities, and structure of IMSVISUAL, as well as the relationship of IMSVISUAL with the Americas Committee for Treatment and Research in MS (ACTRIMS). Finally, we provide an overview of the work IMSVISUAL has completed to date, as well as an outline of research projects ongoing under the auspices of IMSVISUAL.

resultsIMSVISUAL has 140 members worldwide and continues to grow. Through IMSVISUAL-related research, optical coherence tomography (OCT)-derived peripapillary retinal nerve fiber layer (pRNFL) thinning has been established as a predictor of future disability in MS. IMSVISUAL has also developed guidelines for reporting OCT studies in MS. Moreover, a systematic review performed by IMSVISUAL found that not only are pRNFL and ganglion cell + inner plexiform layer (GCIPL) thicknesses reduced in patients with MS (particularly in eyes with prior optic neuritis [ON]), but that inner nuclear layer measures may be higher among MS ON eyes, relative to healthy control eyes. Currently, there are several ongoing IMSVISUAL projects that will establish a role for visual outcomes in diagnosing MS and quantifying the effects of emerging therapies in clinical trials.

conclusionsThe development of IMSVISUAL represents a major collaborative commitment to defining the role of visual outcomes in high-quality, large-scale studies that generate definitive and instructive findings in the field of MS. As a consortium, IMSVISUAL has completed several international collaborative projects, is actively engaged in numerous ongoing research studies, and is committed to expanding the role of vision research in MS and related disorders.

Indexed as

Disease ManagementEye DiseasesOphthalmologyPractice Guidelines as TopicVisual AcuityBiomedical ResearchHumansMultiple Sclerosis

Identifiers

PMID30418332
PMCPMC8898562

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.