Evidence map›Paper›PMID 30418130›Full record

ReviewBlood transfusion = Trasfusione del sangue2019

Platelet cut-off for anticoagulant therapy in thrombocytopenic patients with blood cancer and venous thromboembolism: an expert consensus.

Mariasanta Napolitano, Giorgia Saccullo, Marco Marietta, Monica Carpenedo, Giancarlo Castaman, Elisabetta Cerchiara, Antonio Chistolini, Laura Contino, Valerio De Stefano, Anna Falanga and 27 more

Open access · greenAbstract readReviewConsensus Statement
In one paragraph

Review in Blood transfusion = Trasfusione del sangue, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Risk Assessment for Venous Thrombosis in Lymphoma and Emerging Biomarkers.International journal of molecular sciences · 2026
    Review
  4. Anticoagulant therapy in patients with cancer and thrombocytopenia.Journal of thrombosis and thrombolysis · 2025
    Review
  5. Article
  6. Article
  7. An unusual cause of fatal pulmonary embolism: A case report.Respiratory medicine case reports · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Observational
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 9 institutions in 5 countries.

Mariasanta NapolitanoHaematology Unit, Thrombosis and Haemostasis Reference Regional Center, University of Palermo, Palermo, Italy.
Giorgia SacculloSheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, United Kingdom.
Marco MariettaHaemostasis and Thrombosis Unit, Department of Haematology and Oncology, University Hospital of Modena, Modena, Italy.
Monica CarpenedoHaematology and Transplant Unit, A.O. "San Gerardo", University of Milan "Bicocca", Milan, Italy.
Giancarlo CastamanCentre for Bleeding Disorders and Coagulation, Department of Oncology, "Careggi" University Hospital, Florence, Italy.
Elisabetta CerchiaraDepartment of Haematology and Stem Cell Transplantation, "Campus Bio-Medico" University Hospital, Rome, Italy.
Antonio ChistoliniHaematology Department, "Umberto I" Polyclinic Hospital, "La Sapienza" University of Rome Rome, Italy.
Laura ContinoHaemostasis and Thrombosis Center, Haematology Unit, "SS Antonio e Biagio" Hospital, Alessandria, Italy.
Valerio De StefanoInstitute of Haematology, Catholic University, "A. Gemelli" Academic Hospital, Rome, Italy.
Anna FalangaDepartment of Immunohematology and Transfusion Medicine and the Haemostasis and Thrombosis Center, "Papa Giovanni XXIII" Hospital, Bergamo, Italy.
Augusto B FedericiHaematology and Transfusion Medicine, "Luigi Sacco" University Hospital, Department of Oncology and Onco-Haematology, University of Milan, Milan, Italy.
Elena RossiInstitute of Haematology, Catholic University, "A. Gemelli" Academic Hospital, Rome, Italy.
Rita SantoroHaemostasis and Thrombosis Center, Onco-Haematology Unit, "Pugliese-Ciaccio" Hospital, Catanzaro, Italy.
Sergio SiragusaHaematology Unit, Thrombosis and Haemostasis Reference Regional Center, University of Palermo, Palermo, Italy.
Gruppo Italiano Malattie EMatologiche dell’Adulto (GIMEMA) Working Party on Thrombosis and Hemostasis
Gruppo Italiano Malattie Ematologiche dell’Adulto (GIMEMA) Working Party on Thrombosis and Haemostasis (see Appendix 1)
Valerio De StefanoRome.
Anna FalangaBergamo.
Alberto TosettoVicenza.
Giuseppe AvvisatiRome.
Monica CarpenedoMilan.
Augusto B FedericiMilan.
Marco MariettaModena.
Mariasanta NapolitanoPalermo.
Elena RossiRome.
Cristina SantoroRome.
Giancarlo CastamanFlorence.
Elisabetta CerchiaraRome.
Antonio ChistoliniRome.
Laura ContinoAlessandria.
Maria Gabriella MazzucconiRome.
Ilaria NicheleVicenza.
Laura RussoBergamo.
Roberto SantiAlessandria.
Rita Carlotta SantoroCatanzaro.
Sergio SiragusaPalermo.
Giuseppe TagarielloCastelfranco Veneto.
Azienda Sanitaria Locale Alessandria · ITMylan (Switzerland) · CHUniversity of Bergamo · ITUniversity of Palermo · ITUniversity of Palermo · ARFlorence (Netherlands) · NLOspedale Papa Giovanni XXIII · ITOspedaliero di Castelfranco Veneto · ITRoyal Hallamshire Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundManagement of venous thromboembolism (VTE) in patients with haematologic malignancies and thrombocytopenia is clinically challenging due to the related risks. No prospective studies or clinical trials have been carried out and, therefore, no solid evidence on this compelling issue is available.

methodsGiven this, an expert panel endorsed by the Gruppo Italiano Malattie Ematologiche dell'Adulto Working Party on Thrombosis and Haemostasis was set up to produce a formal consensus, according to the RAND method, in order to issue clinical recommendations about the platelet (PLT) cut-off for safe administration of low molecular weight heparin (LMWH) in thrombocytopenic (PLT <100×10

resultsIn acute VTE, the panel suggests safe anticoagulation with LMWH at therapeutic doses for PLT between ≥50<100×10 DISCUSSION: We suggest using dose-adjusted LMWH according to PLT to optimise anticoagulant treatment in patients at high bleeding risk.

Indexed as

ConsensusHematologic NeoplasmsThrombocytopeniaVenous ThromboembolismAnticoagulantsBlood PlateletsHeparin, Low-Molecular-WeightHumansPlatelet CountAnticoagulantsHeparin, Low-Molecular-Weight

Identifiers

PMID30418130
PMCPMC6596377
OpenAlexW2950662079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.