ArticleJournal of empirical research on human research ethics : JERHRE2018
"Why Don't You Go Into Suburbs? Why Are You Targeting Us?": Trust and Mistrust in HIV Vaccine Trials in South Africa.
Article in Journal of empirical research on human research ethics : JERHRE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Engagement of adolescent girls and young women into an early oral PrEP open-label study in Southern Africa: lessons learned from HPTN 082.BMC public health · 2025Trial
- Provider and Patient Perspectives of Rapid ART Initiation and Streamlined HIV Care: Qualitative Insights From Eastern African Communities.Journal of the International Association of Providers of AIDS CareTrial
- Predictors of COVID-19 vaccination status among youth in eThekwini, South Africa: results from the AYAZAZI RIGHTS study.Global health action · 2026Article
- Looking Down the Road: Development of a Future Syphilis Vaccine.Sexually transmitted diseases · 2026Article
- Bridging Trust and Collaborative Research in Low-Income Contexts During Public Health Emergencies: A Sierra Leone Case Study.Health science reports · 2025Article
- Recruiters' lived experiences in COVID-19 vaccine trials in eThekwini, KwaZulu-Natal.Health SA = SA Gesondheid · 2025Article
- Exploring views of South African research ethics committees on pandemic preparedness and response during COVID-19.Research ethics · 2024Article
- Trust in Medical Research: A Comparative Study among Patients at a Regional Referral Hospital and Community Members in Lira District, Northern Uganda.Journal of empirical research on human research ethics : JERHRE · 2024Article
- Pandemic preparedness: why humanities and social sciences matter.Frontiers in public health · 2024Article
- Article
- A qualitative study of stakeholder and researcher perspectives of community engagement practices for HIV vaccine clinical trials in South Africa.Journal of community psychology · 2023Article
- The role of community advisory boards in community-based HIV clinical trials: a qualitative study from Tanzania.BMC medical ethics · 2022Article
- Attitudes towards and experiences with economic incentives for engagement in HIV care and treatment: Qualitative insights from a randomized trial in Kenya.PLOS global public health · 2022Article
- Expanding community engagement in HIV clinical trials: a pilot study using crowdsourcing.AIDS (London, England) · 2020Article
- Broadening community engagement in clinical research: Designing and assessing a pilot crowdsourcing project to obtain community feedback on an HIV clinical trial.Clinical trials (London, England) · 2020Article
- Researcher and study participants' perspectives of consent in clinical studies in four referral hospitals in Vietnam.BMC medical ethics · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Trust is a key element of high-quality stakeholder relations, which are themselves essential for the success of HIV vaccine trials. Where trust is absent, community stakeholders might not volunteer to become involved in key trial activities, and potential participants might not volunteer for enrollment. We explored site staff and Community Advisory Board (CAB) members' experiences of trust/mistrust among community members and potential participants. We analyzed 10 focus group discussions with site staff and CAB members at two active South African HIV vaccine trial sites. We report on key characteristics perceived to contribute to the trustworthiness of communicators, as well as factors associated with mistrust. Attributes associated with trustworthy communicators included shared racial identity, competence, and independence (not being "captured"). Key foci for mistrust included explanations about site selection, stored samples, vaccination, and Vaccine Induced Sero-Positivity (VISP). Our findings suggest that community members' trust is not necessarily global, in which trials are trusted or not; rather, it appears fairly nuanced and is impacted by various perceived attributes of communicators and the information they provide. We make recommendations for clinical trial site stakeholders invested in building trust and for future research into trust at these sites.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.